Complex CD14:LY96:MYD88:TIRAP:TLR2/4* map
Complex composition:

  1. CD14 map
  2. TIRAP map
  3. MYD88 map
  4. LY96 map
  5. TLR2/4* map

CD14:​LY96:​MYD88:​TIRAP:​TLR2/4*@INNATE_IMMUNE_CELL_Membrane

Identifiers
NAME:CD14:LY96:MYD88:TIRAP:TLR2/4*

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Innate Immunity  map  / IMMUNOSTIMULATORY_CYTOKINE_PATHWAYS  map

References
PMID:17704786, PMID:20547845
HMGB1 interacts with TLR4/LY96(MD2) complex and is internalized with the TLR4 complex after cell surface binding.
PMID:16267105
HMGB1 interacts with TLR2.
TLR2/TLR4 signaling downstream of HMGB1 acts via MYD88 pathway.
PMID:14660645, PMID:16878026, PMID:23681101
The adaptor proteins MyD88 and TIRAP associate with TLR 2 and TLR 4 after receptor engagement.
Transfection of dominant negative MyD88 or TIRAP inhibited almost all of the HMGB1- and LPS-induced NF-??B activation.
MyD88 recruits members of the death domain-containing serine/threonine IL-1R-associated kinase (IRAK) family.
PMID:23508573
Signaling of HMGB1 through TLR4 in macrophages requires CD14

Modifications:
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. CD14:​LY96:​MYD88:​TIRAP:​TLR2/4*@INNATE_IMMUNE_CELL_Membrane map
Participates in reactions:
As Reactant or Product:
  1. TLR2/4*@INNATE_IMMUNE_CELL_Membrane map + LY96@INNATE_IMMUNE_CELL_Membrane map + TIRAP@INNATE_IMMUNE_CELL_Membrane map + MYD88@INNATE_IMMUNE_CELL_Membrane map + CD14@INNATE_IMMUNE_CELL_Membrane map → map CD14:​LY96:​MYD88:​TIRAP:​TLR2/4*@INNATE_IMMUNE_CELL_Membrane map
  2. IRAK2@INNATE_IMMUNE_CELL_Membrane map + IRAK4@INNATE_IMMUNE_CELL_Membrane map + CD14:​LY96:​MYD88:​TIRAP:​TLR2/4*@INNATE_IMMUNE_CELL_Membrane map → map CD14:​IRAK2:​IRAK4:​LY96:​MYD88:​TIRAP:​TLR2/4*@INNATE_IMMUNE_CELL_Membrane map
As Catalyser: