Protein IRAK4 map

Identifiers
interleukin 1 receptor associated kinase 4
HUGO:IRAK4 hgnc_id:HGNC:17967 HGNC:17967 ENTREZ:51135 UNIPROT:Q9NWZ3
HUGO:IRAK4

Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts  map  / INFLAMMATORY_SIGNALING_PATHWAYS  map
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Innate Immunity  map  / IMMUNOSTIMULATORY_CYTOKINE_PATHWAYS  map

References
PMID:12620219
MyD88 mediates a close interaction of the two related IRAK molecules,
which is essential to allow IRAK-4 to phosphorylate IRAK-1. Phosphorylation of IRAK-1
reduces its affinity for MyD88, while increasing its affinity for TRAF6
PMID:12682231
IL18 signaling induces IRAK4 activation (phosphorylation) and activate JNK/AP1 pathway via IRAK4

Modifications:
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. IRAK4@INNATE_IMMUNE_CELL_Membrane map
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. IL18:​IL18R1:​IL18RAP:​IRAK4:​MYD88@INNATE_IMMUNE_CELL_Membrane map
  2. CD14:​IRAK2:​IRAK4:​LY96:​MYD88:​TIRAP:​TLR2/4*@INNATE_IMMUNE_CELL_Membrane map
Participates in reactions:
As Reactant or Product:
  1. IRAK2@INNATE_IMMUNE_CELL_Membrane map + IRAK4@INNATE_IMMUNE_CELL_Membrane map + CD14:​LY96:​MYD88:​TIRAP:​TLR2/4*@INNATE_IMMUNE_CELL_Membrane map → map CD14:​IRAK2:​IRAK4:​LY96:​MYD88:​TIRAP:​TLR2/4*@INNATE_IMMUNE_CELL_Membrane map
  2. IL18@default map + IL18R1:​IL18RAP@INNATE_IMMUNE_CELL_Membrane map + MYD88@INNATE_IMMUNE_CELL_Membrane map + IRAK4@INNATE_IMMUNE_CELL_Membrane map → map IL18:​IL18R1:​IL18RAP:​IRAK4:​MYD88@INNATE_IMMUNE_CELL_Membrane map
As Catalyser:
  1. CCL3@INNATE_IMMUNE_CELL_Cytosol map → map CCL3@default map
  2. gSOCS3@INNATE_IMMUNE_CELL_Cytosol map → map rSOCS3@INNATE_IMMUNE_CELL_Cytosol map
  3. TGFB*@INNATE_IMMUNE_CELL_Cytosol map → map TGFB*@default map
  4. CCL2@INNATE_IMMUNE_CELL_Cytosol map → map CCL2@default map
  5. VEGFA@INNATE_IMMUNE_CELL_Cytosol map → map VEGFA@default map
  6. CXCL2@INNATE_IMMUNE_CELL_Cytosol map → map CXCL2@default map
  7. gIDO1@INNATE_IMMUNE_CELL_Cytosol map → map rIDO1@INNATE_IMMUNE_CELL_Cytosol map
  8. TIMP2@INNATE_IMMUNE_CELL_Cytosol map → map TIMP2@INNATE_IMMUNE_CELL_Membrane map
  9. TIMP1@INNATE_IMMUNE_CELL_Cytosol map → map TIMP1@INNATE_IMMUNE_CELL_Membrane map
  10. gIL10@INNATE_IMMUNE_CELL_Cytosol map → map rIL10@INNATE_IMMUNE_CELL_Cytosol map
  11. Caspase1*:​NLRP3:​PYCARD@INNATE_IMMUNE_CELL_Cytosol map → map (NLRP3:​PYCARD:​cleaved Caspase1*)|​active@INNATE_IMMUNE_CELL_Cytosol map
  12. gIL6@INNATE_IMMUNE_CELL_Cytosol map → map rIL6@INNATE_IMMUNE_CELL_Cytosol map
  13. gCXCL10@INNATE_IMMUNE_CELL_Cytosol map → map rCXCL10@INNATE_IMMUNE_CELL_Cytosol map
  14. gIL23A@INNATE_IMMUNE_CELL_Cytosol map → map rIL23A@INNATE_IMMUNE_CELL_Cytosol map
  15. IRAK1@INNATE_IMMUNE_CELL_Cytosol map → map IRAK1|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map
  16. gFLT3@INNATE_IMMUNE_CELL_Cytosol map → map rFLT3@INNATE_IMMUNE_CELL_Cytosol map