Protein TIMP1 map

Identifiers
TIMP metallopeptidase inhibitor 1
HUGO:TIMP1 hgnc_id:HGNC:11820 HGNC:11820 ENTREZ:7076 UNIPROT:P01033
"tissue inhibitor of metalloproteinase 1"
HUGO:TIMP1 HGNC:11820 ENTREZ:7076 UNIPROT:P01033
HUGO:TIMP1

Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts  map  / MATRIX_REGULATION  map
 EMT Senescence  map  / EMT_REGULATORS  map
 EMT Senescence  map  / ECM  map
 Innate Immunity  map  / TUMOR_GROWTH  map

References
CASCADE:TGFB
CASCADE:IL6
CASCADE:LIF
CASCADE:IL1
PMID:11279127
Dominant-Negative Smad3 and Inhibitory Smad7 Expression Block TGF-??-induced ECM Promoter Activation in fibroblasts
COL1A2, COL3A1, COL6A1, COL6A3, and TIMP-1
 MACROPHAGE  map
CASCADE:TLR2_4
PMID:1629188
TIMP1 and TIMP2 are produced by macrophages.
TIMP1 production is upregulated by TLR4 (LPS) TIMP2 production is inhibited by TLR4 signaling.
PMID:24174628
Angiogenic capacity of M1- and M2-polarized macrophages is determined by the levels of TIMP-1 complexed with their secreted proMMP-9

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. TIMP1@INNATE_IMMUNE_CELL_Cytosol map
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. TIMP1@INNATE_IMMUNE_CELL_Membrane map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. TIMP1@INNATE_IMMUNE_CELL_Membrane map → map MATRIX_REMODELLING@default map
    2. TIMP1@INNATE_IMMUNE_CELL_Cytosol map → map TIMP1@INNATE_IMMUNE_CELL_Membrane map
    As Catalyser: