Identifiers
C-C motif chemokine ligand 3
HUGO:CCL3 hgnc_id:HGNC:10627 HGNC:10627 ENTREZ:6348 UNIPROT:P10147
HUGO:CCL3
Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
Cancer Associated Fibroblasts / CYTOKINES_CHEMOKINES_PRODUCTION
HMC:AVOIDING_IMMUNE_DESTRUCTION
Innate Immunity / RECRUITMENT_OF_IMMUNE_CELLS
References
PMID:19847259
In fibroblasts PTEN inhibit ETS2 expression; and AKT and JNK induce phosphorylqtion of ETS2. MMP9 and CCL3 are the direct targets of this transcription factor.
NEUTROPHIL
MACROPHAGE
DENDRITIC_CELL
CASCADE:TGFB
CASCADE:CCR5
CASCADE:TLR2_4
PMID:19732719??
Inhibition of TGF-?? signaling downregulates Arginase1, CCL5 and CCL2 expression and upregulates TNF, ICAM1,CCL3 expression (mRNA) in tumor neutrophiles (TAN)
PMID:11698286
IFNA induces surface expression of CCR5 in Dcs. This higher expression of CCR5 was associated with a stronger chemotactic response of IFN-DCs to the ??-chemokines CCL5(RANTES), CCL3(MIP-1??), and, especially, CCL4( MIP-1??).
PMID:16410834
T-bet upregulates the production of proinflammatory cytokine IL-1?? and chemokines macrophage inflammatory protein-1?? (MIP-1??) and downregulatesthymus- and activation-related chemokine (TARC) by DCs.
References
in_re570( Innate Immunity ):
PMID:17681149
PPARG participates in inhibition of secretion of proinflammatory molecules, such as CCL-3, TNF, and MCP-1 (CCL-2).
PMID:23508573
HMGB1 induces secretion of CCL2, CCL3 and CXCL10 (IP-10) via TLR4 pathway.