Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
Innate Immunity / RECRUITMENT_OF_IMMUNE_CELLS
References
DENDRITIC_CELL
NATURAL_KILLER
CASCADE:CCR5
CASCADE:IFNAB
PMID:11698286
IFNA induces surface expression of CCR5 in Dcs. This higher expression of CCR5 was associated with a stronger chemotactic response of IFN-DCs to the ??-chemokines CCL5(RANTES), CCL3(MIP-1??), and, especially, CCL4( MIP-1??).
PMID:11790543, PMID:15356122
CCR5 as a critical NK-cell homing receptor,
CCL5 expression at the tumor site determined the effectiveness of the antitumor response, which was associated with infiltration of increased numbers of NK, CD4, and CD8 cells at the tumor site.