RNA CCL3 map

Identifiers
HUGO:CCL3

Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts  map  / CYTOKINES_CHEMOKINES_PRODUCTION  map
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Innate Immunity  map  / RECRUITMENT_OF_IMMUNE_CELLS  map

References
PMID:19847259
In fibroblasts PTEN inhibit ETS2 expression; and AKT and JNK induce phosphorylqtion of ETS2. MMP9 and CCL3 are the direct targets of this transcription factor.

rCCL3@INNATE_IMMUNE_CELL_Cytosol

References
in_re568( Innate Immunity  map ):
PMID:16127449
PPARG sumoilated by PIAS1/UbC9 prevents dissociation of the NCoR???HDAC3 complex fro promoters and transrepresses expression NOS2, Ccl3, Ccl7, Cxcl10
in_re570( Innate Immunity  map ):
PMID:17681149
PPARG participates in inhibition of secretion of proinflammatory molecules, such as CCL-3, TNF, and MCP-1 (CCL-2).
PMID:23508573
HMGB1 induces secretion of CCL2, CCL3 and CXCL10 (IP-10) via TLR4 pathway.

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. rCCL3@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. gCCL3@INNATE_IMMUNE_CELL_Cytosol map → map rCCL3@INNATE_IMMUNE_CELL_Cytosol map
    2. rCCL3@INNATE_IMMUNE_CELL_Cytosol map → map CCL3@INNATE_IMMUNE_CELL_Cytosol map
    As Catalyser: