Protein CXCL2 map

Identifiers
C-X-C motif chemokine ligand 2
HUGO:CXCL2 hgnc_id:HGNC:4603 HGNC:4603 ENTREZ:2920 UNIPROT:P19875
HUGO:CXCL2

Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts  map  / CYTOKINES_CHEMOKINES_PRODUCTION  map
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Innate Immunity  map  / RECRUITMENT_OF_IMMUNE_CELLS  map

References
CASCADE:IL1
PMID:23567181
inhibition of NF-??B signaling, driving expression of CXCL1 and CXCL2 in skin CAFs resulted in decreased macrophage infiltration into transplanted skin tumors, and reduced tumor growth, indicating a central role for CAFs in facilitating the trafficking of macrophages into tumors
PMID:18776941
Expression of VEGF and bFGF, but also IL-1??, MMP9, CCL2, and CXCL2 is STAT3-dependent in myeloid cells.

CXCL2@INNATE_IMMUNE_CELL_Cytosol

References
in_re577:( Innate Immunity  map ) TLR4 signaling downstream of HMGB1 induces secretion of CXCL2 (MIP2).

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. CXCL2@INNATE_IMMUNE_CELL_Cytosol map
In compartment: default
  1. CXCL2@default map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. CXCL2@INNATE_IMMUNE_CELL_Cytosol map → map CXCL2@default map
    2. rCXCL2@INNATE_IMMUNE_CELL_Cytosol map → map CXCL2@INNATE_IMMUNE_CELL_Cytosol map
    As Catalyser: