Gene IDO1 map

Identifiers
HUGO:IDO1

References
 DENDRITIC_CELL  map
 MACROPHAGE  map
CASCADE:IFNG
CASCADE:TLR2_4
CASCADE:TNF
PMID:11477543
TLR4 -induced systemic IDO is largely dependent on TNF-alpha rather than IFN-gamma in macrophages.
PMID:8663541
IFNG induces IDO expression via STAT1 and IRF-1
PMID:19075017
Indoleamine 2,3-dioxygenase (IDO) catalyzes the initial and rate-limiting step in the degradation of tryptophan and is strongly induced in interferon-?? (IFN??)-stimulated dendritic cells (DCs). IDO has recently been established as a key enzyme in T-cell suppression-mediated immune tolerance to tumors.

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. gIDO1@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. gIDO1@INNATE_IMMUNE_CELL_Cytosol map → map rIDO1@INNATE_IMMUNE_CELL_Cytosol map
    As Catalyser: