Reaction state_transition in_re696 map

IRAK1@INNATE_IMMUNE_CELL_Cytosol map → IRAK1|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map

Reaction regulators:
Catalysis
  1. IL18:​IL18R1:​IL18RAP:​IRAK4:​MYD88@INNATE_IMMUNE_CELL_Membrane map
  2. CD14:​IRAK2:​IRAK4:​LY96:​MYD88:​TIRAP:​TLR2/4*@INNATE_IMMUNE_CELL_Membrane map


References
PMID:12620219
MyD88 mediates a close interaction of the two related IRAK molecules,
which is essential to allow IRAK-4 to phosphorylate IRAK-1. Phosphorylation of IRAK-1
reduces its affinity for MyD88, while increasing its affinity for TRAF6