Protein TIMP2 map

Identifiers
TIMP metallopeptidase inhibitor 2
HUGO:TIMP2 hgnc_id:HGNC:11821 HGNC:11821 ENTREZ:7077 UNIPROT:P16035
HUGO:TIMP2
"tissue inhibitor of metalloproteinase 2"
HUGO:TIMP2 HGNC:11821 ENTREZ:7077 UNIPROT:P16035

Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts  map  / MATRIX_REGULATION  map
 EMT Senescence  map  / EMT_REGULATORS  map
 EMT Senescence  map  / ECM  map
 Innate Immunity  map  / TUMOR_GROWTH  map

References
PMID:1323219
MMP2 and TIMP2 are axpressed by CAFS
 MACROPHAGE  map
 MDSC  map
CASCADE:TLR2_4
PMID:1629188
TIMP1 and TIMP2 are produced by macrophages.
TIMP1 production is upregulated by TLR4 (LPS) TIMP2 production is inhibited by TLR4 signaling.
PMID:22735808
TIMP-2 as a negative regulator of MDSCs in tumors
PMID:24437600
TIMP2 drives "normalization" of the tumor microenvironment

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. TIMP2@INNATE_IMMUNE_CELL_Cytosol map
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. TIMP2@INNATE_IMMUNE_CELL_Membrane map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. TIMP2@INNATE_IMMUNE_CELL_Membrane map → map MATRIX_REMODELLING@default map
    2. TIMP2@INNATE_IMMUNE_CELL_Cytosol map → map TIMP2@INNATE_IMMUNE_CELL_Membrane map
    As Catalyser: