Gene FLT3 map

Identifiers
HUGO:FLT3

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Innate Immunity  map  / IMMUNOSTIMULATORY_CYTOKINE_PATHWAYS  map

References
 DENDRITIC_CELL  map
CASCADE:TLR2_4
CASCADE:FLT3LG
PMID:20510871
PU.1 as a critical regulator of both conventional and plasmacytoid DC development. It is directly upregulates Flt3?? gene activation.
PMID:16418395
FLT3L induces PU.1 and STAT3 mRNA expression in DC progenitors and downregulates GATA1 mRNA expression. At The same time enforced expression of??STAT3??or??PU.1??in DC progenitors led to the up-regulation of Flt3??mRNA levels, so there is a positive loop in this signaling. ??Enforced??STAT3??or??PU.1??expression instructs progenitors to differentiate into Dcs. Additionaly it induces expression of cytokine receptors for G-CSF,??M-CSF, and??GM-CSF probably downstream of STAT3.
PMID:25215878
Expression of FLT3 receptor mRNA is upregulated by FLT3L in DCs, but Flt-3 expression on mDC was significantly down-regulated by LPS (TLR4 signaling) and this was not reversed by the presence of FLT3L .??

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. gFLT3@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. gFLT3@INNATE_IMMUNE_CELL_Cytosol map → map rFLT3@INNATE_IMMUNE_CELL_Cytosol map
    As Catalyser: