Protein TLR2/4* map

Identifiers
HUGO:TLR2 HUGO:TLR4

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Innate Immunity  map  / IMMUNOSTIMULATORY_CYTOKINE_PATHWAYS  map

References
PMID:16713974, PMID:14607900
IL10 and Stat3 mediate feedback inhibition of TLR signaling. TLR2/TLR4 induces
IL10 expression. IL10 inhibits exppression of TNF downstream of TLR.
PMID:21826665
TLR4/PI3K signaling in TAN promotes motility of cancer cells

Modifications:
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. TLR2/4*@INNATE_IMMUNE_CELL_Membrane map
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. CD14:​LY96:​MYD88:​TIRAP:​TLR2/4*@INNATE_IMMUNE_CELL_Membrane map
  2. CD14:​IRAK2:​IRAK4:​LY96:​MYD88:​TIRAP:​TLR2/4*@INNATE_IMMUNE_CELL_Membrane map
Participates in reactions:
As Reactant or Product:
  1. TLR4@INNATE_IMMUNE_CELL_Membrane map → map TLR2/4*@INNATE_IMMUNE_CELL_Membrane map
  2. TLR2@INNATE_IMMUNE_CELL_Membrane map → map TLR2/4*@INNATE_IMMUNE_CELL_Membrane map
  3. TLR2/4*@INNATE_IMMUNE_CELL_Membrane map + LY96@INNATE_IMMUNE_CELL_Membrane map + TIRAP@INNATE_IMMUNE_CELL_Membrane map + MYD88@INNATE_IMMUNE_CELL_Membrane map + CD14@INNATE_IMMUNE_CELL_Membrane map → map CD14:​LY96:​MYD88:​TIRAP:​TLR2/4*@INNATE_IMMUNE_CELL_Membrane map
  4. IRAK2@INNATE_IMMUNE_CELL_Membrane map + IRAK4@INNATE_IMMUNE_CELL_Membrane map + CD14:​LY96:​MYD88:​TIRAP:​TLR2/4*@INNATE_IMMUNE_CELL_Membrane map → map CD14:​IRAK2:​IRAK4:​LY96:​MYD88:​TIRAP:​TLR2/4*@INNATE_IMMUNE_CELL_Membrane map
As Catalyser:
  1. CCL3@INNATE_IMMUNE_CELL_Cytosol map → map CCL3@default map
  2. gSOCS3@INNATE_IMMUNE_CELL_Cytosol map → map rSOCS3@INNATE_IMMUNE_CELL_Cytosol map
  3. TGFB*@INNATE_IMMUNE_CELL_Cytosol map → map TGFB*@default map
  4. CCL2@INNATE_IMMUNE_CELL_Cytosol map → map CCL2@default map
  5. VEGFA@INNATE_IMMUNE_CELL_Cytosol map → map VEGFA@default map
  6. CXCL2@INNATE_IMMUNE_CELL_Cytosol map → map CXCL2@default map
  7. gIDO1@INNATE_IMMUNE_CELL_Cytosol map → map rIDO1@INNATE_IMMUNE_CELL_Cytosol map
  8. TIMP2@INNATE_IMMUNE_CELL_Cytosol map → map TIMP2@INNATE_IMMUNE_CELL_Membrane map
  9. TIMP1@INNATE_IMMUNE_CELL_Cytosol map → map TIMP1@INNATE_IMMUNE_CELL_Membrane map
  10. gIL10@INNATE_IMMUNE_CELL_Cytosol map → map rIL10@INNATE_IMMUNE_CELL_Cytosol map
  11. Caspase1*:​NLRP3:​PYCARD@INNATE_IMMUNE_CELL_Cytosol map → map (NLRP3:​PYCARD:​cleaved Caspase1*)|​active@INNATE_IMMUNE_CELL_Cytosol map
  12. gIL6@INNATE_IMMUNE_CELL_Cytosol map → map rIL6@INNATE_IMMUNE_CELL_Cytosol map
  13. gCXCL10@INNATE_IMMUNE_CELL_Cytosol map → map rCXCL10@INNATE_IMMUNE_CELL_Cytosol map
  14. gIL23A@INNATE_IMMUNE_CELL_Cytosol map → map rIL23A@INNATE_IMMUNE_CELL_Cytosol map
  15. IRAK1@INNATE_IMMUNE_CELL_Cytosol map → map IRAK1|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map
  16. gFLT3@INNATE_IMMUNE_CELL_Cytosol map → map rFLT3@INNATE_IMMUNE_CELL_Cytosol map