Identifiers
HUGO:ARG1
Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
Innate Immunity / NO_ROS_PRODUCTION
References
PMID:12193690
A hallmark of ???alternative activation??? (M2) of macrophages
is high arginase activity, which competes with inducible NO
synthase for??L-arginine, the common substrate
of both enzymes.
IL-10 induces arginase-2 expression
Up-regulation of IL4RA by IL10 correlates with increased
IL4-dependent expression of arginase-1 (ARG1).
References
in_re471( Innate Immunity ):
PMID:12193690
Up-regulation of IL4RA by IL10 correlates with increased
IL4-dependent expression of arginase-1 (ARG1).
PMID:10925299, PMID:6357187
IL-13 induces de novo synthesis of arginase I mRNA and protein. Probably via STAT6.
PMID:23390297
MIF induces expression of M2 markers ARG1, IL10, stabilin-1, MRC-1, CD23.