Identifiers
HUGO:ARG1
Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
Innate Immunity / NO_ROS_PRODUCTION
References
PMID:12193690, PMID:17476345
A hallmark of ???alternative activation??? (M2) of macrophages
is high arginase activity, which competes with inducible NO
synthase for??L-arginine, the common substrate
of both enzymes. ARG1 activation has been regarded as one of
the most specific markers of M2 macrophages.
PMID:20644162
Human MDSC express AGR1
PMID:12496409
Arg1 is up-regulated in MDSC by IL-4.
Arg1 increases superoxide production in myeloid cells through a pathway that likely utilizes the reductase domain of inducible NO synthase (iNOS), and that superoxide is required for Arg1-dependent suppression of T cell function.
PMID:26819959
TANs (G-MDSC) produced much more ARG1 and ROS than autologous neutrophils and inhibited proliferation of activated autologous T cells and IFN-?? production
References
in_re475( Innate Immunity ):
PMID:10925299
IL13 activates Arginase activity downstream of cAMP/PKA
PMID:14568929, PMID:10925299
IL13 induces arginase activity which results in L-arginin deficiency. L-arginin deficiency impairs iNOS protein synthesis and stability.
p38 MAPK participates in arginase activation??downstream of IL13
in_re477( Innate Immunity ):
PMID:19732719
Inhibition of TGF-?? signaling??in vivo??increases CD11b+??cell cytotoxicity via an oxygen radical-dependent mechanism (superoxide?? and H2O2 production) in neutrophils