Reaction dissociation in_re475 map

L-arginine@INNATE_IMMUNE_CELL_Cytosol map → Urea@INNATE_IMMUNE_CELL_Cytosol map + L-ornitine@INNATE_IMMUNE_CELL_Cytosol map

Reaction regulators:
Catalysis
  1. ARG1@INNATE_IMMUNE_CELL_Cytosol map
  2. ARG2@INNATE_IMMUNE_CELL_Cytosol map
  3. PKA*@INNATE_IMMUNE_CELL_Cytosol map


References
PMID:10925299
IL13 activates Arginase activity downstream of cAMP/PKA
PMID:14568929, PMID:10925299
IL13 induces arginase activity which results in L-arginin deficiency. L-arginin deficiency impairs iNOS protein synthesis and stability.
p38 MAPK participates in arginase activation??downstream of IL13