Protein ARG2 map

Identifiers
HUGO:ARG2

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Innate Immunity  map  / NO_ROS_PRODUCTION  map

References
PMID:12193690
A hallmark of ???alternative activation??? (M2) of macrophages
is high arginase activity, which competes with inducible NO
synthase for??L-arginine, the common substrate
of both enzymes. IL-10 induces ARG2 (arginase-2) expression

ARG2@INNATE_IMMUNE_CELL_Cytosol

References
in_re475( Innate Immunity  map ):
PMID:10925299
IL13 activates Arginase activity downstream of cAMP/PKA
PMID:14568929, PMID:10925299
IL13 induces arginase activity which results in L-arginin deficiency. L-arginin deficiency impairs iNOS protein synthesis and stability.
p38 MAPK participates in arginase activation??downstream of IL13

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. ARG2@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. rARG2@INNATE_IMMUNE_CELL_Cytosol map → map ARG2@INNATE_IMMUNE_CELL_Cytosol map
    As Catalyser:
    1. L-arginine@INNATE_IMMUNE_CELL_Cytosol map → map Urea@INNATE_IMMUNE_CELL_Cytosol map + L-ornitine@INNATE_IMMUNE_CELL_Cytosol map