Identifiers
HUGO:PRKACA HUGO:PRKACB HUGO:PRKACG
HUGO:PRKACA HGNC:9380 ENTREZ:5566 UNIPROT:P17612 GENECARDS:PRKACA HUGO:PRKACB HGNC:9381 ENTREZ:5567 UNIPROT:P22694 GENECARDS:PRKACB HUGO:PRKACG HGNC:9382 ENTREZ:5568 UNIPROT:P22612
Protein kinase cAMP-depenedent catalytic alpha
HUGO:PRKACA HGNC:9380 ENTREZ:5566 UNIPROT:P17612 GENECARDS:PRKACA REACTOME:57845 KEGG:5566 ATLASONC:GC_PRKACA WIKI:PRKACA
Protein kinase cAMP-depenedent catalytic beta
HUGO:PRKACB HGNC:9381 ENTREZ:5567 UNIPROT:P22694 GENECARDS:PRKACB REACTOME:57847 KEGG:5567 ATLASONC:GC_PRKACB WIKI:PRKACB
Protein kinase cAMP-depenedent catalytic gamma
HUGOPRKACG HGNC:9382 ENTREZ:5568 UNIPROT:P22612
Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
Adaptive Immune Response / INHIBITING_CHECKPOINTS
HMC:TUMOR_PROMOTING_INFLAMMATION
Innate Immunity / IMMUNOSUPPPRESSIVE_CORE_PATHWAYS
HMC:EVADING_GROWTH_SUPPRESSORS
Survival / HEDGEHOG
References
PMID:11181701 PMID:17371980
REACTOME:57845 KEGG:5566 ATLASONC:GC_PRKACA WIKI:PRKACA
REACTOME:57847 KEGG:5567 ATLASONC:GC_PRKACB WIKI:PRKACB
PMID:18501881, PMID:7890616
Intracellular Ca2+??release induces cAMP Accumulation in Human Monocytes and activation of PKA signaling downstream of IL13.
IL-13 significantly inhibits the ROS generation in all macrophage types, probably, via PLC/Ca2+/cAMP/PKA pathway
PMID:10925299
IL13 activates Arginase activity downstream of cAMP/PKA
PMID:20027184
References
in_re475( Innate Immunity ):
PMID:10925299
IL13 activates Arginase activity downstream of cAMP/PKA
PMID:14568929, PMID:10925299
IL13 induces arginase activity which results in L-arginin deficiency. L-arginin deficiency impairs iNOS protein synthesis and stability.
p38 MAPK participates in arginase activation??downstream of IL13
+ PKA*:PKA_R*@INNATE_IMMUNE_CELL_Cytosol → PKA*:PKA_R*:cAMP@INNATE_IMMUNE_CELL_Cytosol
→ PKA_R*:cAMP@INNATE_IMMUNE_CELL_Cytosol + PKA*@INNATE_IMMUNE_CELL_Cytosol
→ ROS_production@default