Identifiers
HUGO:VEGFA
vascular endothelial growth factor A
HUGO:VEGFA, HGNC:12680, ENTREZ:7422, GENECARDS:GC06P043737
HUGO:VEGFA HGNC:12680 ENTREZ:7422 UNIPROT:P15692
Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
Cancer Associated Fibroblasts / GROWTH_FACTORS_PRODUCTION
EMT Senescence / EMT_REGULATORS
EMT Senescence / ECM
Innate Immunity / TUMOR_GROWTH
References
CASCADE:IL6
PMID:24346288
IL-6 promoted VEGF expression by fibroblasts but not by cancer cell lines
PMID:12629515; PMID:11960372
Probably IL6 induces VEGF expression in fibroblasts via STAT3
PMID:9157999
VEGF increased the level of ETS1 mRNA in human umbifical vein endothelial cells and lung microvascular endothelial cells over 5-fold.
Protein levels were shown to increase concordantly.
PMID:11166270
VEGF stands for the vascular Endothelial Growth Factor family of ligands and receptors is crucial for vascular development and neovascularization in physiological and pathological processes in both embryos, and in adults
PMID:13678960
VEGFs belong to a family of homodimeric glycoproteins that containts five members (VEGF-A, B, C, D, and Placenta growth factor PLGF).
VEGFs bind to 3 different VEGF-receptor tyrosine kinases (VEGFR-1, 2, 3).
Upon ligation, VEGF-receptors dimerize, autophosphorylate and, thereby transduce signals that direct cellular functions.
PMID:21372296
HMGB1 markedly increased the expression of the genes for VEGF, and TGFB1 in
peritoneal macrophages.
PMID:23390297, PMID:22461508
MIF signaling induces angiogenesis provavly via upregulation of MMP9, VEGF expression.
PMID:22067385
c-MYC is expressed in tumor-associated macrophages, and its inhibition blocks the expression of protumoral genes including VEGF, MMP9, HIF-1A, and TGFB.
PMID:20644162
Cytokine-induced CD33+ human MDSCs have upregulated iNOS, TGF??, VEGF.
PMID:18776941
Myeloid-derived suppressor cells and macrophages isolated from mouse tumors displayed activated Stat3 and induced angiogenesis in an in vitro tube formation assay via Stat3 induction of angiogenic factors, including VEGF and bFGF.
PMID:25043024
Lactic acid is sufficient to induce Vegf and Arg1 via HIF1??.
Lactic acid, probably via HIF1A polarizes macrophages to an M2-Iike state that is critical for tumour growth
MIF signaling induces angiogenesis probavly via upregulation of MMP9, VEGF expression in macrophages and activates tumor invasion
PMID:20237412
IFN-?? regulates expression of homing and angiogenic factors in neutrophils.
IFNB downregulates expression Cxcr4, Vegf, and Mmp9 in neutrophils
additionally Stat3 and c-myc are downregulated by IFN-??.
(STAT3 is known to be required for full activation of the Cxcr4 gene )
References
in_re631( Innate Immunity ):
PMID:21372296
HMGB1 markedly increased the expression of the genes for VEGF, and TGFB1 in
peritoneal macrophages via TLR4-dependent mechanisms.
PMID:21765015
CSF2 upregulates VEGF expression via HIF1a specific inhibition of PHD2 increases VEGF production
PMID:23390297, PMID:22461508
MIF signaling induces angiogenesis provavly via upregulation of MMP9, VEGF expression.