RNA VEGFA map

Identifiers
HUGO:VEGFA
vascular endothelial growth factor A
HUGO:VEGFA, HGNC:12680, ENTREZ:7422, GENECARDS:GC06P043737
HUGO:VEGFA HGNC:12680 ENTREZ:7422 UNIPROT:P15692

Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts  map  / GROWTH_FACTORS_PRODUCTION  map
 EMT Senescence  map  / EMT_REGULATORS  map
 EMT Senescence  map  / ECM  map
 Innate Immunity  map  / TUMOR_GROWTH  map

References
CASCADE:IL6
PMID:24346288
IL-6 promoted VEGF expression by fibroblasts but not by cancer cell lines
PMID:12629515; PMID:11960372
Probably IL6 induces VEGF expression in fibroblasts via STAT3
PMID:9157999
VEGF increased the level of ETS1 mRNA in human umbifical vein endothelial cells and lung microvascular endothelial cells over 5-fold.
Protein levels were shown to increase concordantly.
PMID:11166270
VEGF stands for the vascular Endothelial Growth Factor family of ligands and receptors is crucial for vascular development and neovascularization in physiological and pathological processes in both embryos, and in adults
PMID:13678960
VEGFs belong to a family of homodimeric glycoproteins that containts five members (VEGF-A, B, C, D, and Placenta growth factor PLGF).
VEGFs bind to 3 different VEGF-receptor tyrosine kinases (VEGFR-1, 2, 3).
Upon ligation, VEGF-receptors dimerize, autophosphorylate and, thereby transduce signals that direct cellular functions.
HMGB1 markedly increased the expression of the genes for VEGF, and TGFB1 in
peritoneal macrophages.
PMID:23390297, PMID:22461508
MIF signaling induces angiogenesis provavly via upregulation of MMP9, VEGF expression.
PMID:22067385
c-MYC is expressed in tumor-associated macrophages, and its inhibition blocks the expression of protumoral genes including VEGF, MMP9, HIF-1A, and TGFB.
PMID:20644162
Cytokine-induced CD33+ human MDSCs have upregulated iNOS, TGF??, VEGF.
MIF signaling induces angiogenesis probavly via upregulation of MMP9, VEGF expression in macrophages and activates tumor invasion

rVEGFA@INNATE_IMMUNE_CELL_Cytosol

References
in_re631( Innate Immunity  map ):
PMID:21372296
HMGB1 markedly increased the expression of the genes for VEGF, and TGFB1 in
peritoneal macrophages via TLR4-dependent mechanisms.
PMID:21765015
CSF2 upregulates VEGF expression via HIF1a specific inhibition of PHD2 increases VEGF production
PMID:23390297, PMID:22461508
MIF signaling induces angiogenesis provavly via upregulation of MMP9, VEGF expression.

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. rVEGFA@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. gVEGFA@INNATE_IMMUNE_CELL_Cytosol map → map rVEGFA@INNATE_IMMUNE_CELL_Cytosol map
    2. rVEGFA@INNATE_IMMUNE_CELL_Cytosol map → map VEGFA@INNATE_IMMUNE_CELL_Cytosol map
    As Catalyser: