→ rTNF@INNATE_IMMUNE_CELL_Cytosol References
PMID:12907458
Bcl-3??? ???interacted with NF-??B p50,
both Bcl-3??? ???and p50??? ???were recruited to the TNF promoter,
BCL3??? ??? and??? ???p50??? ???NFkB recruitment to??? ???TNF ???promoter
prevents binding of??? ???p65/p50??? ???NFkB??? ???heterodimers
to??? ???TNF promotor and suppresses??? ???TNF ???expression
downstream of??? ???IL10.
PMID:17485448
Inhibition of??? ???NFkB signaling downstream of??? ???ABIN3??? ???
inhibits expression of??? ???IL8,??? ???IL6,??? ???TNF,??? ???IL12.
PMID:15465827
BCL3 forms complex with HDAC1 and
repression of the TNF promoter by BCL3
requires Histone Deacetylase Activity.
BCL3 inhibits expression of TNF.
PMID:11875494
HMOX1 (HO1) mediates IL-10-induced suppression of TNF production.
PMID:16878026, PMID:14660645, PMID:15644117, PMID:10952726
Increased TNF expression downstream of HMGB1 is regulated via MYD88 and probably NFkB.
PMID:10754326
Human TNF-alpha gene has binding sites for NF-kappa B. By transient transfection,
NF-kappa B p65 and p50 synergistically activated the TNF-alpha promoter.
Although both the kappa B1 and kappa B3 sites bound transcriptionally active NF-kappa B p50/p65 heterodimers, only the kappa B1 site contributed to down-regulation by NF-kappa B p50 homodimers.
PMID:17404308
CSF1 downregulates TNF, IL-23p19, IL-12p40 expression probably via induction of acomulation of p50 homodimer and inhibition of p65/p50 NF-kB signaling.
CSF2 upregulates expression of TNF, and have positive influence on IL12p70 (p40+p35), IL23 (p40+p19) expression, probably via induction rapid IkBa degradetion, RELA nuclear translocation and formation p65/p50 heterodimers provided induction of NFkB signaling.
PMID:7594497
TGFB1 and IL10 dowregulate expression of TNF.
PMID:23390297
MIF inhitits expression of M1 markers such as TNF.