Identifiers
HUGO:NFATC1 HGNC:7775 ENTREZ:4772 UNIPROT:O95644 GENECARDS:NFATC1 HUGO:NFATC3 HGNC:7777 ENTREZ:4775 UNIPROT:Q12968 GENECARDS:NFATC3 HUGO:NFATC2 HGNC:7776 ENTREZ:4773 UNIPROT:Q13469 GENECARDS:NFATC2 HUGO:NFATC4 HGNC:7778 ENTREZ:4776 UNIPROT:Q14934 GENECARDS:NFATC4 HUGO:NFAT5 HGNC:7774 ENTREZ:10725 UNIPROT:O94916 GENECARDS:NFAT5
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
HUGO:NFATC1
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
HUGO:NFATC2
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
HUGO:NFATC3
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
HUGO:NFATC4
nuclear activator of activated T-cells 5, tonicity-responsive
HUGO:NFAT5
HUGO:NFATC1 HGNC:7775 ENTREZ:4772 UNIPROT:O95644
HUGO:NFATC3 HGNC:7777 ENTREZ:4775 UNIPROT:Q12968
HUGO:NFATC1 HGNC:7775 ENTREZ:4772 UNIPROT:O95644 GENECARDS:NFATC1 REACTOME:60119 KEGG:4772 ATLASONC:GC_NFATC1 WIKI:NFATC1
HUGO:NFATC3 HGNC:7777 ENTREZ:4775 UNIPROT:Q12968 GENECARDS:NFATC3 REACTOME:60123 KEGG:4775 ATLASONC:GC_NFATC3 WIKI:NFATC3
NF-ATP, NFAT1, NFATp
HUGO:NFATC2 HGNC:7776 ENTREZ:4773 UNIPROT:Q13469 GENECARDS:NFATC2 REACTOME:60121 KEGG:4773 ATLASONC:NFATC2ID44004ch20q13 WIKI:NFATC2
NF-ATC, NFAT2, NFATc
NFAT3
HUGO:NFATC4 HGNC:7778 ENTREZ:4776 UNIPROT:Q14934 GENECARDS:NFATC4 KEGG:4776 ATLASONC:GC_NFATC4 WIKI:NFATC4
UNIIPROT:Q149934
nuclear factor of activated T-cells 5, tonicity-responsive
NFAT5
HUGO:NFAT5 HGNC:7774 ENTREZ:10725 UNIPROT:O94916 GENECARDS:NFAT5 KEGG:10725 ATLASONC:GC_NFAT5 WIKI:NFAT5
Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
Adaptive Immune Response / TCR_SIGNALING
Innate Immunity / MIRNA_TF_IMMUNOSTIMULATORY
HMC:EVADING_GROWTH_SUPPRESSORS
Survival / MAPK
Survival / WNT_NON_CANONICAL
References
PMID:11148124 PMID:8068174 PMID:10811803 PMID:11262396 PMID:10898494 PMID:19836308 PMID:11406367
nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 1
REACTOME:60119 KEGG:4772 ATLASONC:GC_NFATC1 WIKI:NFATC1
nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 3
REACTOME:60123 KEGG:4775 ATLASONC:GC_NFATC3 WIKI:NFATC3
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
NF-ATP, NFAT1, NFATp
REACTOME:60121 KEGG:4773 ATLASONC:NFATC2ID44004ch20q13 WIKI:NFATC2
NF-ATC, NFAT2, NFATc
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
NFAT3
KEGG:4776 ATLASONC:GC_NFATC4 WIKI:NFATC4
UNIIPROT:Q149934
nuclear factor of activated T-cells 5, tonicity-responsive
NFAT5
KEGG:10725 ATLASONC:GC_NFAT5 WIKI:NFAT5
CASCADE:Fc_gamma_RIII
NATURAL_KILLER
PMID:10089876, PMID:7650486, PMID:9973469
??Ca('2+)??activates Calmodulin 2 (??Calmodulin??)/ Protein phosphatase 3 (Calcineurin??) signal. Activated??Calcineurin??dephosphorylates Nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 2 (??NF-AT1(NFATC2)??).??
This signaling is activated downstream of CD16 in NK cells
PMID:7650486, PMID:9973469, PMID:9374532
NF-AT, migrates to the nucleus and activates transcription of cytokines TNF, ??GM-CSF??, IL-2, ??IL-4. Fas ligand (??FasL??)??and, possibly, IFNG.
NFAT sites are often located close to AP-1 sites in many promoters allowing for cooperative binding and synergistic trans-activation of numerous genes. NFATc1 is crucial to the differentiation of Th cells to the Th2 effector phenotype.
PMID:11274345
NFAT1 has at least 21 phosphorylation sites, 18 are located within the regulatory domain, 14 are conserved in the NFAT family 13 are dephosphorylated upon stimulation which is required to cause full exposure of NLS, mask an NES, needed for full activation: 7 serine residues in SRR1 domain of which 5 are phosphorylated (S170, S173, S174, S176, S177, S179, and S182), S215, S219, S223, S238, S245, S270, S276, S278, S282, and S2328.
PMID:11030334
NFAT5 activity is not regulated by phosphorylation but osmotic stress
PMID:11402342
References
in_re1031( Innate Immunity ):
PMID:12907458
Bcl-3??? ???interacted with NF-??B p50,
both Bcl-3??? ???and p50??? ???were recruited to the TNF promoter,
BCL3??? ??? and??? ???p50??? ???NFkB recruitment to??? ???TNF ???promoter
prevents binding of??? ???p65/p50??? ???NFkB??? ???heterodimers
to??? ???TNF promotor and suppresses??? ???TNF ???expression
downstream of??? ???IL10.
PMID:17485448
Inhibition of??? ???NFkB signaling downstream of??? ???ABIN3??? ???
inhibits expression of??? ???IL8,??? ???IL6,??? ???TNF,??? ???IL12.
PMID:15465827
BCL3 forms complex with HDAC1 and
repression of the TNF promoter by BCL3
requires Histone Deacetylase Activity.
BCL3 inhibits expression of TNF.
PMID:11875494
HMOX1 (HO1) mediates IL-10-induced suppression of TNF production.
PMID:16878026, PMID:14660645, PMID:15644117, PMID:10952726
Increased TNF expression downstream of HMGB1 is regulated via MYD88 and probably NFkB.
PMID:10754326
Human TNF-alpha gene has binding sites for NF-kappa B. By transient transfection,
NF-kappa B p65 and p50 synergistically activated the TNF-alpha promoter.
Although both the kappa B1 and kappa B3 sites bound transcriptionally active NF-kappa B p50/p65 heterodimers, only the kappa B1 site contributed to down-regulation by NF-kappa B p50 homodimers.
PMID:17404308
CSF1 downregulates TNF, IL-23p19, IL-12p40 expression probably via induction of acomulation of p50 homodimer and inhibition of p65/p50 NF-kB signaling.
CSF2 upregulates expression of TNF, and have positive influence on IL12p70 (p40+p35), IL23 (p40+p19) expression, probably via induction rapid IkBa degradetion, RELA nuclear translocation and formation p65/p50 heterodimers provided induction of NFkB signaling.
PMID:7594497
TGFB1 and IL10 dowregulate expression of TNF.
PMID:23390297
MIF inhitits expression of M1 markers such as TNF.
→ NFAT*@INNATE_IMMUNE_CELL_Cytosol
→ NFAT*@INNATE_IMMUNE_CELL_Cytosol
→ rTNF@INNATE_IMMUNE_CELL_Cytosol
→ rIL2@INNATE_IMMUNE_CELL_Cytosol
→ rCSF2@INNATE_IMMUNE_CELL_Cytosol
→ rIL4@INNATE_IMMUNE_CELL_Cytosol
→ rIFNG@INNATE_IMMUNE_CELL_Cytosol
→ rFASL*@INNATE_IMMUNE_CELL_Cytosol