Simple molecule lactic acid map
lactic acid @default

Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
 Innate Immunity  map  / IMMUNOSUPPRESSIVE_CYTOKINE_PATHWAYS  map

References
CASCADE:LACTIC
 DENDRITIC_CELL  map
 MACROPHAGE  map
PMID:25043024
Lactic acid is sufficient to induce Vegf and Arg1 via HIF1??.
Lactic acid, probably via HIF1A polarizes macrophages to an M2-Iike state that is critical for tumour growth
PMID:16278308, PMID:23506875
Lactate is transported into the cell probably by the monocarboxylate transporters (MCTs) and this process is strictly pH dependent
Tumor-derived lactic acid inhibits DC maturation and T cell activation.

lactic acid @INNATE_IMMUNE_CELL_Cytosol

Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
 Innate Immunity  map  / IMMUNOSUPPRESSIVE_CYTOKINE_PATHWAYS  map

References
CASCADE:LACTIC
 DENDRITIC_CELL  map
 MACROPHAGE  map
PMID:25043024
Lactic acid is sufficient to induce Vegf and Arg1 via HIF1??.
Lactic acid, probably via HIF1A polarizes macrophages to an M2-Iike state that is critical for tumour growth
PMID:16278308, PMID:23506875
Lactate is transported into the cell probably by the monocarboxylate transporters (MCTs) and this process is strictly pH dependent
Tumor-derived lactic acid inhibits DC maturation and T cell activation.

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. lactic acid @INNATE_IMMUNE_CELL_Cytosol map
In compartment: default
  1. lactic acid @default map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. lactic acid @default map → map lactic acid @INNATE_IMMUNE_CELL_Cytosol map
    2. lactic acid @INNATE_IMMUNE_CELL_Cytosol map → map IMMUNE_SUPRESSION@default map
    3. Hypoxia@TUMOR_CELL_AS_INDUCTOR map → map lactic acid @default map
    As Catalyser:
    1. HIF1A@INNATE_IMMUNE_CELL_Cytosol map → map HIF1A@INNATE_IMMUNE_CELL_Cytosol map