Identifiers
HUGO:EPAS1

Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
 Innate Immunity   / MIRNA_TF_IMMUNOSUPPRESSIVE 

References
PMID:20194441
HIF2a expression is assosiated with M2 phenotype.
PMID:11888900, PMID:20644254
HIF2A induces tumor growth and angiogenesis.
PMID:16127144
HIF-1A and HIF-2A are up-regulated by human macrophages exposed to hypoxia??in vitro??and by TAMs in hypoxic/necrotic areas of human tumors
PMID:20644254
HIF2a induces macrophage migration via upregulation of CXCR4, FN1 expression and upregulation of M-CSFR protein level.
PMID:21765015, PMID:22869907
CSF2 upregulates VEGF expression via HIF1a specific inhibition of PHD2 increases VEGF production.
CSF2 upregulates expression of soluble form of VEGFR (sVEGFR-1) wich inhibits VEGF signaling via HIF2a. specific inhibition of PHD3 increases VEGF production.

References
in_re513( Innate Immunity  ):
PMID:10623817
CCR2 ligands regulates recruiting monocytes/macrophages to tumors.
TNF inhibit CCR2 expression in tumor associated macrophages.

1. HIF2A*@INNATE_IMMUNE_CELL_Cytosol

1. rHIF2A*@INNATE_IMMUNE_CELL_Cytosol → HIF2A*@INNATE_IMMUNE_CELL_Cytosol
2. HIF2A*@INNATE_IMMUNE_CELL_Cytosol → HIF2A*@INNATE_IMMUNE_CELL_Cytosol
3. HIF2A*@INNATE_IMMUNE_CELL_Cytosol → degraded

1. rCSF1R@INNATE_IMMUNE_CELL_Cytosol → CSF1R@INNATE_IMMUNE_CELL_Cytosol
2. gFLT1@INNATE_IMMUNE_CELL_Cytosol → rtrVEGFR1*@INNATE_IMMUNE_CELL_Cytosol
3. gCXCR4@INNATE_IMMUNE_CELL_Cytosol → rCXCR4@INNATE_IMMUNE_CELL_Cytosol
4. gFN1@INNATE_IMMUNE_CELL_Cytosol → rFN1@INNATE_IMMUNE_CELL_Cytosol
5. gCCR2@INNATE_IMMUNE_CELL_Cytosol → rCCR2@INNATE_IMMUNE_CELL_Cytosol
6. gCXCL2@INNATE_IMMUNE_CELL_Cytosol → rCXCL2@INNATE_IMMUNE_CELL_Cytosol