References
NATURAL_KILLER
CASCADE:NKP44
CASCADE:NKP30
PMID:23414611, PMID:19196184, PMID:15294952
Heparin is ligand of NKp30, NKp44 and Nkp46. The NCRs initiate tumor targeting by recognition of??heparan??sulfate??on cancer cells.??Tumor cells expressing cell surface heparanase or lacking membranal heparan manifest reduced recognition by NKp30 and NKp46 and are lysed to a lesser extent by NK cells.
in_re159( Innate Immunity ):
PMID:11062502, PMID:15536084
ERK1/2 activation induces perforin and granzyme B movement towards target tumor cells downstream of PI3K signaling in NK cells.
References
MAST_CELL
PMID:15099563
Mast cells produce heparin, interleukin-8 (IL-8) and vascular
endothelial cell growth factor (VEGF), which induce
neovascularization,