Protein IL1B map

Identifiers
HUGO:IL18
interleukin 1 beta
HUGO:IL1B hgnc_id:HGNC:5992 HGNC:5992 ENTREZ:3553 UNIPROT:P01584
HUGO:IL1B
synonyms:interleukin 1 beta

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Adaptive Immune Response  map  / TCR_SIGNALING  map
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts  map  / CYTOKINES_CHEMOKINES_PRODUCTION  map
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / ER_STRESS  map
 Regulated Cell Death  map  / PYROPTOSIS  map
 Innate Immunity  map  / TUMOR_GROWTH  map

References
PMID:27557510
PMID:19747910
Through paracrine signaling molecules, TGF-beta and IL-1beta, cancer cells activate stromal fibroblasts and induce the expression of fibroblast activation protein (FAP). FAP, in turn, affects the proliferation, invasion and migration of the cancer cells. We report that TGF-beta and IL-1beta are important factors in inducing differentiation of myofibroblasts and expression of functional markers, notably alpha-SMA.
PMID:20138012
The role of IL-1?? as a main upstream regulator of NF-???? activation in CAFs was also demonstrated
PMID:26885855
PMID:27048821
PMID:27066895
PMID:17043764
IL1 signaling has both antitumor effect (low dose of IL B and menbran associated IL1A) and protumor effect (high dose of IL1) in tumor microevironment,
PMID:12598651
Microenvironmental IL-1 beta and, to a lesser extent, IL-1 alpha are required for in vivo angiogenesis and invasiveness of different tumor cells.
PMID:24727385
Tumor-derived IL-1?? secreted into the tumor microenvironment has been shown to induce the accumulation of MDSC that promotes tumor growth.
PMID:18977329
IL-1?? activates MDSC in vitro and in vivo through an IL-1RI/NF-??B pathway.
mRNA expression of several NF-??B target genes such is IL6, IL1B,TNF are IL1B/NFkB dependent in MSDC
PMID:17942936
IL-1R???deficient mice have a delayed accumulation of MDSC and reduced primary and metastatic tumor progression. Accumulation of MDSC and tumor progression are partially restored by IL-6, indicating that IL-6 is a downstream mediator of the IL-1?????induced expansion of MDSC. IL-1Ra (IL-1R antagonis) ???/??? MDSC are more suppressive than BALB/c MDSC.
PMID:18633355
TAM express many pro-angiogenic and angiogenesis-modulating factors in vitro, such as VEGF, basic fibroblast growth factor (bFGF, also known as FGF2), tumour necrosis factor (TNF), interleukin 1 (IL1), chemokine (C-X-C motif) ligand 8 (CXCL8; also known as IL8), cyclooxygenase 2 (COX2, also known as PTGS2), plasminogen activator, urokinase (uPA, also known as PLAU), platelet derived growth factor beta.
PMID:15099563
Mast cells produce cytokines TNF-a, TGF-b, IFN-a, IL-1a, IL-1b, IL-5, IL-6,
IL-13, IL-16, IL-18
PMID:21826665
TANs produce TNF and IL1B, probably downstream of TLR4

IL1B@INNATE_IMMUNE_CELL_Cytosol

References
in_re592( Innate Immunity  map ):
PMID:20547845, PMID:10952726
TLR4 signaling downstream of HMGB1 induces secretion of IL1B probably via NFkB

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. IL1B@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. IL1B@INNATE_IMMUNE_CELL_Cytosol map → map trILB1@INNATE_IMMUNE_CELL_Cytosol map
    2. rIL1B@INNATE_IMMUNE_CELL_Cytosol map → map IL1B@INNATE_IMMUNE_CELL_Cytosol map
    As Catalyser: