RNA IL1B map

Identifiers
HUGO:IL18
HUGO:IL1B

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Adaptive Immune Response  map  / TCR_SIGNALING  map
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts  map  / CYTOKINES_CHEMOKINES_PRODUCTION  map
 Innate Immunity  map  / TUMOR_GROWTH  map

References
PMID:27557510
CASCADE:IL1
PMID:20138012
PTGS2, CXCL1, and CXCL2; the proinflammatory cytokines IL-1?? and IL-6, CYR61 and OPN are upregulated in CAFs,
probably downstream of IL1B via NFkB
PMID:15465827
BCL3 inhibits expression of IL1B.
PMID:18776941
Expression of VEGF and bFGF, but also IL-1??, MMP9, CCL2, and CXCL2 is STAT3-dependent in myeloid cells.

rIL1B@INNATE_IMMUNE_CELL_Cytosol

References
in_re591( Innate Immunity  map ):
PMID:15465827
BCL3 inhibits expression of IL1B.
in_re592( Innate Immunity  map ):
PMID:20547845, PMID:10952726
TLR4 signaling downstream of HMGB1 induces secretion of IL1B probably via NFkB

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. rIL1B@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. gIL1B@INNATE_IMMUNE_CELL_Cytosol map → map rIL1B@INNATE_IMMUNE_CELL_Cytosol map
    2. rIL1B@INNATE_IMMUNE_CELL_Cytosol map → map IL1B@INNATE_IMMUNE_CELL_Cytosol map
    As Catalyser: