Identifiers
HUGO:CBL

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Adaptive Immune Response   / TCR_SIGNALING 
 Innate Immunity   / IMMUNOSTIMULATORY_CORE_PATHWAYS 

References
PMID:11353765
 NATURAL_KILLER 
CASCADE:SLAMF7
CASCADE:2B4
CASCADE:NKG2D
PMID:20189481, PMID:18835194
CBL inhibited Vav1-dependent activation signals in NK via VAV1 ubiquitination.
Tyrosine phosphorylation of c-Cbl was detected after stimulation NKL cells by either NKG2D, 2B4, or the synergistic NKG2D and 2B4 combination.
Cbl Limits NK Cell Activation.
PMID:15169881
2B4 signaling induces phosphorylation of SHIP1,VAV1,CBL.
This phosphorylation is dependent on SAP and FYN.

1. CBL@INNATE_IMMUNE_CELL_Cytosol
2. CBL|​pho|​active@INNATE_IMMUNE_CELL_Cytosol

1. (BCAR1|​pho:​CBL|​pho:​CRK:​CRKL:​RAPGEF1)|​active@INNATE_IMMUNE_CELL_Cytosol
2. BCAR1|​pho:​CBL|​pho:​CRKL|​pho:​CRK|​pho:​RAPGEF1@INNATE_IMMUNE_CELL_Cytosol

1. CBL@INNATE_IMMUNE_CELL_Cytosol → CBL|​pho|​active@INNATE_IMMUNE_CELL_Cytosol
2. (BCAR1|​pho:​CBL|​pho:​CRK:​CRKL:​RAPGEF1)|​active@INNATE_IMMUNE_CELL_Cytosol → BCAR1|​pho:​CBL|​pho:​CRKL|​pho:​CRK|​pho:​RAPGEF1@INNATE_IMMUNE_CELL_Cytosol
3. BCAR1@INNATE_IMMUNE_CELL_Cytosol + RAPGEF1@INNATE_IMMUNE_CELL_Cytosol + CBL|​pho|​active@INNATE_IMMUNE_CELL_Cytosol + CRK@INNATE_IMMUNE_CELL_Cytosol + CRKL@INNATE_IMMUNE_CELL_Cytosol → (BCAR1|​pho:​CBL|​pho:​CRK:​CRKL:​RAPGEF1)|​active@INNATE_IMMUNE_CELL_Cytosol
4. BCAR1|​pho:​CBL|​pho:​CRKL|​pho:​CRK|​pho:​RAPGEF1@INNATE_IMMUNE_CELL_Cytosol → RAPGEF1@INNATE_IMMUNE_CELL_Cytosol + BCAR1@INNATE_IMMUNE_CELL_Cytosol + CBL|​pho|​active@INNATE_IMMUNE_CELL_Cytosol + CRK|​pho@INNATE_IMMUNE_CELL_Cytosol + CRKL|​pho@INNATE_IMMUNE_CELL_Cytosol + CRKL@INNATE_IMMUNE_CELL_Cytosol

1. VAV1@INNATE_IMMUNE_CELL_Cytosol → VAV1|​ubi@INNATE_IMMUNE_CELL_Cytosol
2. GDP:​RAP1A@INNATE_IMMUNE_CELL_Cytosol + GTP@INNATE_IMMUNE_CELL_Cytosol → (GTP:​RAP1A)|​active@INNATE_IMMUNE_CELL_Cytosol + GDP@INNATE_IMMUNE_CELL_Cytosol