Protein CRK map

Identifiers
HUGO:CRK HGNC:2362
v-crk sarcoma virus CT10 oncogene homolog (avian)
"v-crk avian sarcoma virus CT10 oncogene homolog"
HUGO:CRK HGNC:2362 ENTREZ:1398 UNIPROT:P46108
HUGO:CRK

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map
 EMT Senescence  map  / CELL_MATRIX_ADHESIONS  map
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Innate Immunity  map  / IMMUNOSTIMULATORY_CORE_PATHWAYS  map

References
PMID:16076871
PMID:16000375
Src and FAK kinases cooperate to phosphorylate paxillin, stimulate its focal adhesion localization, and regulate cell spreading and protrusiveness.
Phosphorylated paxillin binding to Crk is implicated in Rac activation and stimulation of cell motility
PMID:15308668
CRK bound to DOCK1 (so-called DOCK180) forms complex with phosphorylated paxillin.
The complex is necessary for collagen-dependent cell migration, mainly through Rac1 activation.
CASCADE:KIR2DL1
CASCADE:NKG2A
CASCADE:INTEGRIN_AVB5
 NATURAL_KILLER  map
 DENDRITIC_CELL  map
PMID:18835194
Through its SH3 domain, CRK (CrkII) recruits the GEF C3G, which activates the GTPase Rap in NK cells.
Association of CrkII with c-Cbl, p130CAS, and C3G was induced by activation of NK cells.
Association of CrkII with ALBL1(c-Abl) occurred during inhibition. ABL1 phosphorylates CRK and inhibits CRK activity.
PMID:22464172
The intensity of p-Vav1 in Crk-silenced NK cells was decreased

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. CRK@INNATE_IMMUNE_CELL_Cytosol map
  2. CRK|​pho@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. BCAR1:​CRK:​DOCK1@INNATE_IMMUNE_CELL_Cytosol map
  2. (BCAR1|​pho:​CBL|​pho:​CRK:​CRKL:​RAPGEF1)|​active@INNATE_IMMUNE_CELL_Cytosol map
  3. BCAR1|​pho:​CBL|​pho:​CRKL|​pho:​CRK|​pho:​RAPGEF1@INNATE_IMMUNE_CELL_Cytosol map
Participates in reactions:
As Reactant or Product:
  1. (BCAR1|​pho:​CBL|​pho:​CRK:​CRKL:​RAPGEF1)|​active@INNATE_IMMUNE_CELL_Cytosol map → map BCAR1|​pho:​CBL|​pho:​CRKL|​pho:​CRK|​pho:​RAPGEF1@INNATE_IMMUNE_CELL_Cytosol map
  2. BCAR1@INNATE_IMMUNE_CELL_Cytosol map + RAPGEF1@INNATE_IMMUNE_CELL_Cytosol map + CBL|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map + CRK@INNATE_IMMUNE_CELL_Cytosol map + CRKL@INNATE_IMMUNE_CELL_Cytosol map → map (BCAR1|​pho:​CBL|​pho:​CRK:​CRKL:​RAPGEF1)|​active@INNATE_IMMUNE_CELL_Cytosol map
  3. BCAR1|​pho:​CBL|​pho:​CRKL|​pho:​CRK|​pho:​RAPGEF1@INNATE_IMMUNE_CELL_Cytosol map → map RAPGEF1@INNATE_IMMUNE_CELL_Cytosol map + BCAR1@INNATE_IMMUNE_CELL_Cytosol map + CBL|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map + CRK|​pho@INNATE_IMMUNE_CELL_Cytosol map + CRKL|​pho@INNATE_IMMUNE_CELL_Cytosol map + CRKL@INNATE_IMMUNE_CELL_Cytosol map
  4. CRK@INNATE_IMMUNE_CELL_Cytosol map + DOCK1@INNATE_IMMUNE_CELL_Cytosol map + BCAR1@INNATE_IMMUNE_CELL_Cytosol map → map BCAR1:​CRK:​DOCK1@INNATE_IMMUNE_CELL_Cytosol map
As Catalyser:
  1. GDP:​RAC1_2*@INNATE_IMMUNE_CELL_Cytosol map + GTP@INNATE_IMMUNE_CELL_Cytosol map → map (GTP:​RAC1_2*)|​active@INNATE_IMMUNE_CELL_Cytosol map + GDP@INNATE_IMMUNE_CELL_Cytosol map
  2. VAV1@INNATE_IMMUNE_CELL_Cytosol map → map VAV1|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map
  3. GDP:​RAP1A@INNATE_IMMUNE_CELL_Cytosol map + GTP@INNATE_IMMUNE_CELL_Cytosol map → map (GTP:​RAP1A)|​active@INNATE_IMMUNE_CELL_Cytosol map + GDP@INNATE_IMMUNE_CELL_Cytosol map