Complex BCAR1:CRK:DOCK1
Complex composition:
- BCAR1
- CRK
- DOCK1
BCAR1:CRK:DOCK1@INNATE_IMMUNE_CELL_Cytosol
Identifiers
NAME:BCAR1:CRK:DOCK1
Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
Innate Immunity
/ IMMUNOSTIMULATORY_CORE_PATHWAYS
References
MACROPHAGE
CASCADE:INTEGRIN_AVB5
PMID:14697347, PMID:??11146654
Integrin ??v??5 regulates phagocytosis via CRK /DOCK1 (DOCK180) /RAC1 pathway downstream of.
Integrin ??v??5 activation results in recruitment of the p130cas???CrkII???Dock180 complex and RAC1 activation.
in_re167( Innate Immunity
):
PMID:??12094222??
VAV proteins activate RAC1 via induction of GDP/GTP exchange.
Modifications:
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Cytosol
- BCAR1:CRK:DOCK1@INNATE_IMMUNE_CELL_Cytosol
Participates in reactions:
As Reactant or Product:- CRK@INNATE_IMMUNE_CELL_Cytosol
+ DOCK1@INNATE_IMMUNE_CELL_Cytosol
+ BCAR1@INNATE_IMMUNE_CELL_Cytosol
→
BCAR1:CRK:DOCK1@INNATE_IMMUNE_CELL_Cytosol
As Catalyser:- GDP:RAC1_2*@INNATE_IMMUNE_CELL_Cytosol
+ GTP@INNATE_IMMUNE_CELL_Cytosol
→
(GTP:RAC1_2*)|active@INNATE_IMMUNE_CELL_Cytosol
+ GDP@INNATE_IMMUNE_CELL_Cytosol