Identifiers
dedicator of cytokinesis 1
"dedicator of cyto-kinesis 1"
HUGO:DOCK1 HGNC:2987 ENTREZ:1793 UNIPROT:Q14185
HUGO:DOC1
Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
EMT Senescence / EMT_REGULATORS
EMT Senescence / CYTOSKELETON_POLARITY
HMC:AVOIDING_IMMUNE_DESTRUCTION
Innate Immunity / IMMUNOSTIMULATORY_CORE_PATHWAYS
References
PMID:15308668
DOCK1 (so-called DOCK180) is a GEF of Rac1.
DOCK1 together with paxillin-Crk constitutes the main pathway transducing collagen-mediated signals for the activation of Rac1.
This signaling pathway is down-regulated when cell migration is counteracted by C3G/Rap1 activation.
A balance between Rac1 and Rap1 GTPases in controlling the migratory versus the stationary state of the cell is suggested.
PMID:12432077
DOCK1 is a GEF for Rac1 and possibly for CDC42
PMID:9808620
DOCK1 is involved in integrin signaling through Crk-p130Cas complexes.
DOCK1 activates JNK in a Rac1, Cdc42 - dependent manner
Overexpression of DOCK1 increases the amount of GTP-bound Rac1
Coexpression of Crk2 and p130Cas (BCAR1) enhances this DOCK1-dependent activation of Rac1.
Direct binding of DOCK1 to Rac1, but not to RhoA or Cdc42.
To sum up, DOCK1 is a novel activator of Rac1 and involved in integrin signaling.
DENDRITIC_CELL
CASCADE:INTEGRIN_AVB5
PMID:14697347, PMID:11146654
Integrin ??v??5 regulates phagocytosis via CRK /DOCK1 (DOCK180) /RAC1 pathway downstream of.
Integrin ??v??5 activation results in recruitment of the p130cas???CrkII???Dock180 complex and RAC1 activation.