Protein BCAR1 map

Identifiers
breast cancer anti-estrogen resistance 1
HUGO:BCAR1 HGNC:971 ENTREZ:9564 UNIPROT:P56945
HUGO:BCAR1

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map
 EMT Senescence  map  / CELL_MATRIX_ADHESIONS  map
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Innate Immunity  map  / IMMUNOSTIMULATORY_CORE_PATHWAYS  map

References
 DENDRITIC_CELL  map
 NATURAL_KILLER  map
CASCADE:INTEGRIN_AVB5
PMID:18835194
Several YxxP motifs for binding of (CrkII) are also present in the scaffold protein BCAR1 (p130CAS).
Association of CrkII with c-Cbl, p130CAS, and C3G was induced by activation of NK cells.

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. BCAR1@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. BCAR1:​CRK:​DOCK1@INNATE_IMMUNE_CELL_Cytosol map
  2. (BCAR1|​pho:​CBL|​pho:​CRK:​CRKL:​RAPGEF1)|​active@INNATE_IMMUNE_CELL_Cytosol map
  3. BCAR1|​pho:​CBL|​pho:​CRKL|​pho:​CRK|​pho:​RAPGEF1@INNATE_IMMUNE_CELL_Cytosol map
Participates in reactions:
As Reactant or Product:
  1. (BCAR1|​pho:​CBL|​pho:​CRK:​CRKL:​RAPGEF1)|​active@INNATE_IMMUNE_CELL_Cytosol map → map BCAR1|​pho:​CBL|​pho:​CRKL|​pho:​CRK|​pho:​RAPGEF1@INNATE_IMMUNE_CELL_Cytosol map
  2. BCAR1@INNATE_IMMUNE_CELL_Cytosol map + RAPGEF1@INNATE_IMMUNE_CELL_Cytosol map + CBL|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map + CRK@INNATE_IMMUNE_CELL_Cytosol map + CRKL@INNATE_IMMUNE_CELL_Cytosol map → map (BCAR1|​pho:​CBL|​pho:​CRK:​CRKL:​RAPGEF1)|​active@INNATE_IMMUNE_CELL_Cytosol map
  3. BCAR1|​pho:​CBL|​pho:​CRKL|​pho:​CRK|​pho:​RAPGEF1@INNATE_IMMUNE_CELL_Cytosol map → map RAPGEF1@INNATE_IMMUNE_CELL_Cytosol map + BCAR1@INNATE_IMMUNE_CELL_Cytosol map + CBL|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map + CRK|​pho@INNATE_IMMUNE_CELL_Cytosol map + CRKL|​pho@INNATE_IMMUNE_CELL_Cytosol map + CRKL@INNATE_IMMUNE_CELL_Cytosol map
  4. CRK@INNATE_IMMUNE_CELL_Cytosol map + DOCK1@INNATE_IMMUNE_CELL_Cytosol map + BCAR1@INNATE_IMMUNE_CELL_Cytosol map → map BCAR1:​CRK:​DOCK1@INNATE_IMMUNE_CELL_Cytosol map
As Catalyser:
  1. GDP:​RAC1_2*@INNATE_IMMUNE_CELL_Cytosol map + GTP@INNATE_IMMUNE_CELL_Cytosol map → map (GTP:​RAC1_2*)|​active@INNATE_IMMUNE_CELL_Cytosol map + GDP@INNATE_IMMUNE_CELL_Cytosol map
  2. GDP:​RAP1A@INNATE_IMMUNE_CELL_Cytosol map + GTP@INNATE_IMMUNE_CELL_Cytosol map → map (GTP:​RAP1A)|​active@INNATE_IMMUNE_CELL_Cytosol map + GDP@INNATE_IMMUNE_CELL_Cytosol map