Identifiers
NAME:GDP:RAP1A
Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
Innate Immunity / IMMUNOSTIMULATORY_CORE_PATHWAYS
References
NATURAL_KILLER
CASCADE:NKG2D
PMID:19454690
Ligation of either the FcR or NKG2D results in activation of Rap1and induces Rap1-RAPL-MST1 signaling cascade.
Rap1 is activated following FcR and NKG2D ligation in a PI3K- and CrkL-dependent manner.
Rap1 regulates NKG2D-mediated adhesion and MTOC polarization leading to NK cell cytotoxicity.