Protein RAP1A map

Identifiers
RAP1A, member of RAS oncogene family
HUGO:RAP1A, HGNC:9855, ENTREZ:5906, UNIPROT:P62834, GENECARDS:RAP1A
HUGO:RAP1A

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Innate Immunity  map  / IMMUNOSTIMULATORY_CORE_PATHWAYS  map

References
Reviews
PMID:18680434, PMID;PMID:16166375, PMID:19965504
Identification of RAP1A
PMID:10850490
 NATURAL_KILLER  map
CASCADE:NKG2D
PMID:19454690
Ligation of either the FcR or NKG2D results in activation of Rap1and induces Rap1-RAPL-MST1 signaling cascade.
Rap1 is activated following FcR and NKG2D ligation in a PI3K- and CrkL-dependent manner.
Rap1 regulates NKG2D-mediated adhesion and MTOC polarization leading to NK cell cytotoxicity.

Modifications:
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. GDP:​RAP1A@INNATE_IMMUNE_CELL_Cytosol map
  2. (GTP:​RAP1A)|​active@INNATE_IMMUNE_CELL_Cytosol map
Participates in reactions:
As Reactant or Product:
  1. GDP:​RAP1A@INNATE_IMMUNE_CELL_Cytosol map + GTP@INNATE_IMMUNE_CELL_Cytosol map → map (GTP:​RAP1A)|​active@INNATE_IMMUNE_CELL_Cytosol map + GDP@INNATE_IMMUNE_CELL_Cytosol map
  2. (GTP:​RAP1A)|​active@INNATE_IMMUNE_CELL_Cytosol map → map Conjugate_formation@INNATE_IMMUNE_CELL_Membrane map
As Catalyser:
  1. RASSF5@INNATE_IMMUNE_CELL_Cytosol map + MST1@INNATE_IMMUNE_CELL_Cytosol map → map MST1|​pho:​RASSF5@INNATE_IMMUNE_CELL_Cytosol map