Protein RAPGEF1 map

Identifiers
HUGO:RAPGEF1

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Innate Immunity  map  / IMMUNOSTIMULATORY_CORE_PATHWAYS  map

References
 NATURAL_KILLER  map
PMID:18835194
Through its SH3 domain, CRK (CrkII) recruits the GEF C3G, which activates the GTPase Rap in NK cells.
Association of CrkII with c-Cbl, p130CAS, and C3G was induced by activation of NK cells.
RAPGEF1(C3G) activates the GTPase Rap1

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. RAPGEF1@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. (BCAR1|​pho:​CBL|​pho:​CRK:​CRKL:​RAPGEF1)|​active@INNATE_IMMUNE_CELL_Cytosol map
  2. BCAR1|​pho:​CBL|​pho:​CRKL|​pho:​CRK|​pho:​RAPGEF1@INNATE_IMMUNE_CELL_Cytosol map
Participates in reactions:
As Reactant or Product:
  1. (BCAR1|​pho:​CBL|​pho:​CRK:​CRKL:​RAPGEF1)|​active@INNATE_IMMUNE_CELL_Cytosol map → map BCAR1|​pho:​CBL|​pho:​CRKL|​pho:​CRK|​pho:​RAPGEF1@INNATE_IMMUNE_CELL_Cytosol map
  2. BCAR1@INNATE_IMMUNE_CELL_Cytosol map + RAPGEF1@INNATE_IMMUNE_CELL_Cytosol map + CBL|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map + CRK@INNATE_IMMUNE_CELL_Cytosol map + CRKL@INNATE_IMMUNE_CELL_Cytosol map → map (BCAR1|​pho:​CBL|​pho:​CRK:​CRKL:​RAPGEF1)|​active@INNATE_IMMUNE_CELL_Cytosol map
  3. BCAR1|​pho:​CBL|​pho:​CRKL|​pho:​CRK|​pho:​RAPGEF1@INNATE_IMMUNE_CELL_Cytosol map → map RAPGEF1@INNATE_IMMUNE_CELL_Cytosol map + BCAR1@INNATE_IMMUNE_CELL_Cytosol map + CBL|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map + CRK|​pho@INNATE_IMMUNE_CELL_Cytosol map + CRKL|​pho@INNATE_IMMUNE_CELL_Cytosol map + CRKL@INNATE_IMMUNE_CELL_Cytosol map
As Catalyser:
  1. GDP:​RAP1A@INNATE_IMMUNE_CELL_Cytosol map + GTP@INNATE_IMMUNE_CELL_Cytosol map → map (GTP:​RAP1A)|​active@INNATE_IMMUNE_CELL_Cytosol map + GDP@INNATE_IMMUNE_CELL_Cytosol map