Identifiers
HUGO:PLCG2
Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
Innate Immunity / IMMUNOSTIMULATORY_CORE_PATHWAYS
References
CASCADE:SLAMF7
CASCADE:2B4
CASCADE:NKG2D
CASCADE:Fc_gamma_RI
CASCADE:Fc_gamma_RII
CASCADE:Fc_gamma_RIII
CASCADE:IFNAB
NATURAL_KILLER
MACROPHAGE
MAST_CELL
PMID:25960930
IFN?? induces PKC-?? auto-phosphorylation in NK cells via P3K and PLC pathways and improves the degranulation via PKC-?? signaling
PMID:12740575, PMID:15972651, PMID:20189481
NKG2D signaling inducese PLCG2 phosphorylation and Ca2+ release via VAV1. ??The calcium signal generated by PLCG??is required for NKG2D-initiated killing.
PMID:20189481, PMID:22786724, PMID:20189481
DNAM1 signaling stimulate Ca2+??mobilization provably via VAV1/PLC-GAMMA2 pathway in NK cells,
PMID:22683124
PLCG2-deficient NK cells displayed a partial reduction of conjugate formationwith target tumor cells probably via regulation of Ca2+ fluxes,
because a chelator of intracellular Ca2+ also provokes a partial reduction of conjugate formation.
PMID:11169415, PMID:10072481, PMID:8649391, PMID:1281218
Tyrosine phosphorylation of LAT led to the recruitment of intracytoplasmic signaling molecules including phospholipase Cgamma and Grb2
and activation of phosphatidylinositol pathway in NK cells.
PMID:2536067, PMID:1281218
Ligation of??Fc gamma RIII alpha (CD16) ??induces the tyrosine phosphorylation of both phospholipase C (PLC)-gamma 1 and PLC-gamma 2 in natural killer cells and stimulates expression of many cytokines via??Ca('2+)??-depend mechanism.
PMID:8226994
Stimulation of the human monocytic cell line THP-1 by cross-linking either Fc gamma receptor I (Fc gamma RI) or Fc gamma receptor II (Fc gamma RII) gave rise to the rapid phosphorylation of multiple intracellular proteins. The pattern of proteins that were phosphorylated appeared to be identical. Analysis of these proteins by specific immunoprecipitation indicated that stimulation through either receptor did indeed give rise to phosphorylation of the same set of proteins. These included: Fc gamma RII, phospholipase C (PLC) gamma 1, PLC gamma 2, Vav, GAP
PMID:19909365
The phosphorylation of LAT1
together with the generation of PIP3 in the lipid raft environment recruits proteins such as
PLC-??1 and PLC-??2