Identifiers
HUGO:SH2D1A

References
 NATURAL_KILLER 
CASCADE:2B4
CASCADE:IFNAB
CASCADE:IL12
CASCADE:IL2
PMID:10358138
Phosphorylated h2B4 recruits SH2D1A (SAP).
Association of SAP with h2B4 prevents recruitment of PTPN11 (SHP-2).
PMID:15998796, PMID:15169881, PMID:15713798
SAP and FYN are required for the ability of NK cells to eliminate tumor cells in vitro and in vivo
downstream of 2B4. Probably SAP couples Fyn to 2B4.
PMID:22683124
Fyn-Binding Site of SH2D1A (SAP) is necessary for 2B4-Mediated NK Cell activation.
NK cells, those lacking SAP displayed markedly reduced conjugate formation via inhibition of
LFA1-ICAM1 association.

1. SH2D1A@INNATE_IMMUNE_CELL_Membrane

1. 2B4*|​pho:​CD48:​SH2D1A@INNATE_IMMUNE_CELL_Membrane
2. 2B4*|​pho:​3BP2*|​pho:​CD48:​SH2D1A@INNATE_IMMUNE_CELL_Membrane

1. CD48@INNATE_IMMUNE_CELL_Membrane + 2B4*@INNATE_IMMUNE_CELL_Membrane + SH2D1A@INNATE_IMMUNE_CELL_Membrane → 2B4*|​pho:​CD48:​SH2D1A@INNATE_IMMUNE_CELL_Membrane
2. rSH2D1A@INNATE_IMMUNE_CELL_Cytosol → SH2D1A@INNATE_IMMUNE_CELL_Membrane
3. 2B4*|​pho:​CD48:​SH2D1A@INNATE_IMMUNE_CELL_Membrane + 3BP2*|​pho@INNATE_IMMUNE_CELL_Membrane → 2B4*|​pho:​3BP2*|​pho:​CD48:​SH2D1A@INNATE_IMMUNE_CELL_Membrane

1. LCP2@INNATE_IMMUNE_CELL_Cytosol → LCP2|​pho@INNATE_IMMUNE_CELL_Cytosol
2. PLCG2@INNATE_IMMUNE_CELL_Cytosol → PLCG2|​pho@INNATE_IMMUNE_CELL_Cytosol
3. PLCG1@INNATE_IMMUNE_CELL_Cytosol → PLCG1|​pho@INNATE_IMMUNE_CELL_Cytosol
4. DNAM1*|​pho@INNATE_IMMUNE_CELL_Membrane + CD11a*:​CD18*@INNATE_IMMUNE_CELL_Membrane → CD11a*:​CD18*:​DNAM1*|​pho@INNATE_IMMUNE_CELL_Membrane
5. CBL@INNATE_IMMUNE_CELL_Cytosol → CBL|​pho|​active@INNATE_IMMUNE_CELL_Cytosol
6. 3BP2*@INNATE_IMMUNE_CELL_Membrane → 3BP2*|​pho@INNATE_IMMUNE_CELL_Membrane
7. LAT|​pho@INNATE_IMMUNE_CELL_Cytosol → LAT@INNATE_IMMUNE_CELL_Cytosol
8. gFASL*@INNATE_IMMUNE_CELL_Cytosol → rFASL*@INNATE_IMMUNE_CELL_Cytosol