RNA SH2D1A map

Identifiers
HUGO:SH2D1A

References
 NATURAL_KILLER  map
CASCADE:IFNAB
CASCADE:IL12
CASCADE:IL2
PMID:17171759
SAP mRNA expression and protein levels are low in freshly isolated resting NK cells. IL-2 stimulation leads to an up-regulation of SAP expression, which can be enhanced by IL-12, the stimulation of TLR3 by polyinosinic-polycytidylic acid (poly(IC))and to a lesser extent by IFN-??.
The regulation of SAP has functional consequences for the stimulation of NK cell cytotoxicity by 2B4. In resting NK cells, 2B4 stimulation can only enhance NK cell lysis when co-triggered with other activating NK cell receptors. In IL-2-activated NK cells with high SAP expression the triggering of 2B4 alone is sufficient to induce NK cell cytotoxicity, demonstrating a correlation between the regulated SAP expression and the function of 2B4.

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. rSH2D1A@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. gSH2D1A@INNATE_IMMUNE_CELL_Cytosol map → map rSH2D1A@INNATE_IMMUNE_CELL_Cytosol map
    2. rSH2D1A@INNATE_IMMUNE_CELL_Cytosol map → map SH2D1A@INNATE_IMMUNE_CELL_Membrane map
    As Catalyser: