Identifiers
HUGO:SH2D1A
References
NATURAL_KILLER
CASCADE:IFNAB
CASCADE:IL12
CASCADE:IL2
PMID:17171759
SAP mRNA expression and protein levels are low in freshly isolated resting NK cells. IL-2 stimulation leads to an up-regulation of SAP expression, which can be enhanced by IL-12, the stimulation of TLR3 by polyinosinic-polycytidylic acid (poly(IC))and to a lesser extent by IFN-??.