Identifiers
HUGO:NCR1
Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
Innate Immunity / MARKERS_NK
References
NATURAL_KILLER
CASCADE:NKP46
CASCADE:IL2
PMID:23414611
NKp30 (NCR3), NKp44 (NCR2), NKp46 (NCR1) are major activating receptors in NK cells (NCRs). The efficiency of tumour cell killing by NK cells has been shown to correlate with the expression level of the NCRs
PMID:10562324, PMID:11385609, PMID:12731048
NKp30 cooperates with NKp46 and NKp44 in the induction of NK-mediated cytotoxicity probably via the same pathways. The engagement of one NCR appears to be able to activate the signaling cascades associated with the other NCR, possibly resulting in the amplification of the activating signals
PMID:23414611, PMID:23414611, PMID:9625766
Nkp46 (NCR1) is the most specific marker of NK cells reported so far. For signalling, NKp46 associates with CD247 (CD3??) and also with the ??-chain of Fc??RI. Nkp46 signaling is activated by unknown ligands expressed on tumor cells??. Ncr1 knockout mice exhibit an increase in tumour metastasis.
PMID:22267813
NK cells with defective cell-surface expression of NKp46 are hyperreactive in responses to the prototypic NK cell tumor target cell line.
But Ncr1 knockout mice have been reported to be highly susceptible to the infections.
The down-regulation of NK cell activity by NKp46 was associated with the silencing of the Helios transcription factor in NK cells.
PMID:9603467
NKRP1A-induced inhibition of CD16 or p46 mediated cytolytic activity.
PMID:15778339
IL2 stimulates surface expression of KIR2DL4 (2DL4.1)and NKp46
→ CD247:CD247|pho:FCER1G:NKp46*@INNATE_IMMUNE_CELL_Membrane
+ NKp46*@INNATE_IMMUNE_CELL_Membrane + CD247@INNATE_IMMUNE_CELL_Cytosol → CD247:FCER1G:NKp46*@INNATE_IMMUNE_CELL_Membrane
→ NKp46*@INNATE_IMMUNE_CELL_Cytosol
→ NKp46*@INNATE_IMMUNE_CELL_Membrane