Protein CD247 map

Identifiers
HUGO:CD247

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Adaptive Immune Response  map  / SMAC  map
 Innate Immunity  map  / FC_RECEPTORS  map

References
PMID:9738502 PMID:21059766 PMID:11353765
 NATURAL_KILLER  map
 MACROPHAGE  map
CASCADE:NKP46
CASCADE:NKP30
CASCADE:NKG2A
CASCADE:Fc_gamma_RIII
PMID:10562324, PMID:23414611
To initiate signal transduction, NKp30 associates with immunoreceptor tyrosine based activation motif (ITAM)-containing adaptor proteins, such as disulfide-linked homodimers of CD247 (CD3zeta).
PMID:23414611, PMID:23414611, PMID:9625766
Nkp46 (NCR1) is the most specific marker of NK cells reported so far. For signalling, NKp46 associates with CD247 (CD3??) and also with the ??-chain of Fc??RI. Nkp46 signaling is activated by unknown ligands expressed on tumor cells.
PMID:8478617
Fc gamma RIII crosslinking results in activation of the src-related kinase p56lck in NK cells.
CD3 zeta is phosphorilated by LCK

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. CD247@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. CD247:​NKp30*@INNATE_IMMUNE_CELL_Membrane map
  2. CD247:​Fc_gamma_RIII*@INNATE_IMMUNE_CELL_Membrane map
  3. CD247|​pho:​NKp30*@INNATE_IMMUNE_CELL_Membrane map
  4. CD247:​FCER1G:​NKp46*@INNATE_IMMUNE_CELL_Membrane map
  5. CD247:​CD247|​pho:​FCER1G:​NKp46*@INNATE_IMMUNE_CELL_Membrane map
  6. CD247:​CD247|​pho:​FCER1G:​NKp46*@INNATE_IMMUNE_CELL_Membrane map
  7. CD247|​pho:​FCER1G|​pho:​Fc_gamma_RIII*:​Immunoglobulins*@INNATE_IMMUNE_CELL_Membrane map
Participates in reactions:
As Reactant or Product:
  1. CD247:​NKp30*@INNATE_IMMUNE_CELL_Membrane map → map CD247|​pho:​NKp30*@INNATE_IMMUNE_CELL_Membrane map
  2. CD247:​FCER1G:​NKp46*@INNATE_IMMUNE_CELL_Membrane map → map CD247:​CD247|​pho:​FCER1G:​NKp46*@INNATE_IMMUNE_CELL_Membrane map
  3. CD247@INNATE_IMMUNE_CELL_Cytosol map + Fc_gamma_RIII*@INNATE_IMMUNE_CELL_Membrane map → map CD247:​Fc_gamma_RIII*@INNATE_IMMUNE_CELL_Membrane map
  4. CD247@INNATE_IMMUNE_CELL_Cytosol map + NKp30*@INNATE_IMMUNE_CELL_Membrane map → map CD247:​NKp30*@INNATE_IMMUNE_CELL_Membrane map
  5. FCER1G@INNATE_IMMUNE_CELL_Membrane map + NKp46*@INNATE_IMMUNE_CELL_Membrane map + CD247@INNATE_IMMUNE_CELL_Cytosol map → map CD247:​FCER1G:​NKp46*@INNATE_IMMUNE_CELL_Membrane map
  6. CD247:​Fc_gamma_RIII*@INNATE_IMMUNE_CELL_Membrane map + Immunoglobulins*@TUMOR_CELL_AS_INDUCTOR map + FCER1G@INNATE_IMMUNE_CELL_Membrane map → map CD247|​pho:​FCER1G|​pho:​Fc_gamma_RIII*:​Immunoglobulins*@INNATE_IMMUNE_CELL_Membrane map
As Catalyser:
  1. gTBX21@INNATE_IMMUNE_CELL_Cytosol map → map rTBX21@INNATE_IMMUNE_CELL_Cytosol map
  2. SYK@INNATE_IMMUNE_CELL_Cytosol map → map SYK|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map
  3. ZAP70@INNATE_IMMUNE_CELL_Cytosol map → map ZAP70|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map
  4. SHC1@INNATE_IMMUNE_CELL_Cytosol map → map SHC1|​pho@INNATE_IMMUNE_CELL_Cytosol map
  5. IL2@INNATE_IMMUNE_CELL_Cytosol map → map IL2@default map