Protein Immunoglobulins* map

Identifiers
HUGO:IGH HUGO:IGL HUGO:IGK

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Innate Immunity  map  / FC_RECEPTORS  map

References
 NATURAL_KILLER  map
 MACROPHAGE  map
 NEUTROPHIL  map
 MAST_CELL  map
CASCADE:FCGR2B
CASCADE:FCER
CASCADE:FCAR
CASCADE:Fc_gamma_RI
CASCADE:Fc_gamma_RII
CASCADE:Fc_gamma_RIII
PMID:15099567
The cross-linking of immunoglobulin E (IgE) with bivalent or multivalent
antigen results in the aggregation of FceRI, which is sufficient for initiating
down-stream signal transduction events that activate cell degranulation as well
as the de novo synthesis and secretion of lipid mediators and cytokines

Immunoglobulins*@TUMOR_CELL_AS_INDUCTOR

References
in_re258( Innate Immunity  map ):
PMID:8478617
Fc gamma RIII crosslinking results in activation of the src-related kinase p56lck in NK cells.
CD3 zeta is phosphorilated by LCK

Modifications:
In compartment: TUMOR_CELL_AS_INDUCTOR
  1. Immunoglobulins*@TUMOR_CELL_AS_INDUCTOR map
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. Fc_gamma_RII_inhibiting*:​Immunoglobulins*@INNATE_IMMUNE_CELL_Membrane map
  2. Fc_epsilon_R*|​pho:​Immunoglobulins*@INNATE_IMMUNE_CELL_Membrane map
  3. Fc_gamma_RII_activating*|​pho:​Immunoglobulins*@INNATE_IMMUNE_CELL_Membrane map
  4. FCAR:​FCER1G|​pho:​Immunoglobulins*@INNATE_IMMUNE_CELL_Membrane map
  5. FCER1G|​pho:​Fc_gamma_RI*:​Immunoglobulins*@INNATE_IMMUNE_CELL_Membrane map
  6. CD247|​pho:​FCER1G|​pho:​Fc_gamma_RIII*:​Immunoglobulins*@INNATE_IMMUNE_CELL_Membrane map
Participates in reactions:
As Reactant or Product:
  1. CD247:​Fc_gamma_RIII*@INNATE_IMMUNE_CELL_Membrane map + Immunoglobulins*@TUMOR_CELL_AS_INDUCTOR map + FCER1G@INNATE_IMMUNE_CELL_Membrane map → map CD247|​pho:​FCER1G|​pho:​Fc_gamma_RIII*:​Immunoglobulins*@INNATE_IMMUNE_CELL_Membrane map
  2. Immunoglobulins*@TUMOR_CELL_AS_INDUCTOR map + Fc_gamma_RII_inhibiting*@INNATE_IMMUNE_CELL_Membrane map → map Fc_gamma_RII_inhibiting*:​Immunoglobulins*@INNATE_IMMUNE_CELL_Membrane map
  3. Immunoglobulins*@TUMOR_CELL_AS_INDUCTOR map + Fc_gamma_RII_activating*@INNATE_IMMUNE_CELL_Membrane map → map Fc_gamma_RII_activating*|​pho:​Immunoglobulins*@INNATE_IMMUNE_CELL_Membrane map
  4. Immunoglobulins*@TUMOR_CELL_AS_INDUCTOR map + Fc_gamma_RI*@INNATE_IMMUNE_CELL_Membrane map + FCER1G@INNATE_IMMUNE_CELL_Membrane map → map FCER1G|​pho:​Fc_gamma_RI*:​Immunoglobulins*@INNATE_IMMUNE_CELL_Membrane map
  5. Immunoglobulins*@TUMOR_CELL_AS_INDUCTOR map + FCAR@INNATE_IMMUNE_CELL_Membrane map + FCER1G@INNATE_IMMUNE_CELL_Membrane map → map FCAR:​FCER1G|​pho:​Immunoglobulins*@INNATE_IMMUNE_CELL_Membrane map
  6. Immunoglobulins*@TUMOR_CELL_AS_INDUCTOR map + Fc_epsilon_R*@INNATE_IMMUNE_CELL_Membrane map → map Fc_epsilon_R*|​pho:​Immunoglobulins*@INNATE_IMMUNE_CELL_Membrane map
As Catalyser:
  1. TNF@INNATE_IMMUNE_CELL_Cytosol map → map TNF@default map
  2. gTBX21@INNATE_IMMUNE_CELL_Cytosol map → map rTBX21@INNATE_IMMUNE_CELL_Cytosol map
  3. IL6@INNATE_IMMUNE_CELL_Cytosol map → map IL6@default map
  4. SYK@INNATE_IMMUNE_CELL_Cytosol map → map SYK|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map
  5. ZAP70@INNATE_IMMUNE_CELL_Cytosol map → map ZAP70|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map
  6. SHC1@INNATE_IMMUNE_CELL_Cytosol map → map SHC1|​pho@INNATE_IMMUNE_CELL_Cytosol map
  7. FYN@INNATE_IMMUNE_CELL_Cytosol map → map FYN|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map
  8. PTPN6@INNATE_IMMUNE_CELL_Cytosol map → map PTPN6@INNATE_IMMUNE_CELL_Cytosol map
  9. SHIP1*@INNATE_IMMUNE_CELL_Cytosol map → map SHIP1*|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map