Protein Fc_gamma_RII_activating* map

Identifiers
HUGO:FCGR2A HUGO:FCGR2C

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Innate Immunity  map  / FC_RECEPTORS  map

References
 MACROPHAGE  map
 NEUTROPHIL  map
CASCADE:Fc_gamma_RII
PMID:2139103
Fc gamma RI and Fc gamma RII on whichever cells they were expressed were capable of phagocytosing anti-Fc gamma R mAb-coated erythrocytes. Furthermore, Fc gamma RIII on mononuclear phagocytes, which appears to be a conventional integral membrane protein that spans the lipid bilayer, was capable of phagocytosing anti-Fc gamma RIII-coated erythrocytes.
PMID:1238444
FcgammaRIIa-mediated phagocytosis was significantly enhanced in THP-1 cells overexpressing dominant-negative form of SHIP in the absence of FcgammaRII(b). These results indicate that SHIP negatively regulates FcgammaR-mediated phagocytosis through all ITAM-containing IgG receptors
PMID:8132624
Hck, Lyn binds to Fc_gamma_RII (CD32) and phosphorylates it in monocytes.

Modifications:
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. Fc_gamma_RII_activating*@INNATE_IMMUNE_CELL_Membrane map
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. Fc_gamma_RII_activating*|​pho:​Immunoglobulins*@INNATE_IMMUNE_CELL_Membrane map
Participates in reactions:
As Reactant or Product:
  1. Immunoglobulins*@TUMOR_CELL_AS_INDUCTOR map + Fc_gamma_RII_activating*@INNATE_IMMUNE_CELL_Membrane map → map Fc_gamma_RII_activating*|​pho:​Immunoglobulins*@INNATE_IMMUNE_CELL_Membrane map
As Catalyser:
  1. SYK@INNATE_IMMUNE_CELL_Cytosol map → map SYK|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map