Identifiers
HGNC:10840
SHC adaptor protein 1
HUGO:SHC1 hgnc_id:HGNC:10840 HGNC:10840 ENTREZ:6464 UNIPROT:P29353
HUGO:SHC1
Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
Cancer Associated Fibroblasts / CORE
HMC:AVOIDING_IMMUNE_DESTRUCTION
Innate Immunity / IMMUNOSTIMULATORY_CORE_PATHWAYS
References
PMID:19449109 PMID:16076871
CASCADE:FGF
CASCADE:EGFR
PMID:11447289
Grb2 forms a complex with tyrosine-phosphorylated Shc in FGF-stimulated fibroblasts in an FRS2??-independent manner
PMID:10567412; PMID:15567848
EGFR activates ERK via GRB2/SOS/RAS/RAF pathway
EGFR induces SHC phosphorylation, directly interacts with GRB2 and induces formation of SHC:GRB2:SOS activated complex.
NATURAL_KILLER
CASCADE:Fc_gamma_RIII
CASCADE:INTEGRIN_A4B1
CASCADE:INTEGRIN_A5B1
PMID:10849428
IL-2 and IL-15 were the only two cytokines among those tested that were able to induce Shc phosphorylation in NK cells.
PMID:8551221
SHC1 protein is phosphorylated upon CD16 and IL-2R Stimulation in Human NK Cells and interacts with GRB2
PMID:10982827
Shc and GRB2 mediate Gab2 tyrosyl phosphorylation. Mutation of the three tyrosyl phosphorylation sites of Shc, which bind Grb2, blocks the ability of the Shc chimera to evoke Gab2 tyrosyl phosphorylation in B cells.
PMID:11449354, PMID:12393695
CD16 cross-linking on human NK cells induces the association of SHIP-1 with receptor zeta-chain through the adaptor protein shc.
Fc gamma RIII alpha (CD16) autoregulates activation of downstream signals trough CD3 zeta/ Shc/ Inositol polyphosphate-5-phosphatase 145kDa ( SHIP ) pathway. The hypothetical mechanism consists of SHIP participation in inhibition of Ca('2+) -depend pathway and signal from PI3K via decreased amount IP3 [45] and PtdIns(3,4,5)P3.
+ SHC1|pho@INNATE_IMMUNE_CELL_Cytosol → SHC1|pho:SHIP1*|pho@INNATE_IMMUNE_CELL_Cytosol
→ SHC1|pho@INNATE_IMMUNE_CELL_Cytosol
+ SHC1|pho@INNATE_IMMUNE_CELL_Cytosol → GRB2:SHC1|pho@INNATE_IMMUNE_CELL_Cytosol