Simple molecule PIP2*
PIP2*@INNATE_IMMUNE_CELL_Cytosol
References
PMID:12040186
The activated PI3K converts the plasma membrane lipid phosphatidylinositol-4,5-bisphosphate [PI(4,5)P2] to phosphatidylinositol-3,4,5-trisphosphate [PI(3,4,5)P3].
PMID:12393695
SHIP1 inhinits NK cells activation via bloking of PI3K pathway. It hydrolyzes the 5???-phosphate of PI3,4,5P3l eading to its conversion to PI3,4P2.
Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
- PIP2*@INNATE_IMMUNE_CELL_Cytosol
Participates in complexes:
Participates in reactions:
As Reactant or Product:- PIP2*@INNATE_IMMUNE_CELL_Cytosol
→
PIP3*@INNATE_IMMUNE_CELL_Cytosol
- PIP3*@INNATE_IMMUNE_CELL_Cytosol
→
PIP2*@INNATE_IMMUNE_CELL_Cytosol
- PtdIns(4)-P@INNATE_IMMUNE_CELL_Cytosol
→
PIP2*@INNATE_IMMUNE_CELL_Cytosol
- PtdIns(4)-P@INNATE_IMMUNE_CELL_Cytosol
→
PIP2*@INNATE_IMMUNE_CELL_Cytosol
As Catalyser:- PSD4@INNATE_IMMUNE_CELL_Cytosol
→
PSD4@INNATE_IMMUNE_CELL_Cytosol