Simple molecule PIP3* map
PIP3*@INNATE_IMMUNE_CELL_Cytosol

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Innate Immunity  map  / IMMUNOSTIMULATORY_CORE_PATHWAYS  map

References
 NATURAL_KILLER  map
CASCADE:NKP80
CASCADE:NKG2D
CASCADE:IL4
CASCADE:NKP46
CASCADE:Fc_gamma_RIII
CASCADE:IL15
CASCADE:CSF2
CASCADE:IFNG
PMID:11062502, PMID:11385609, PMID:11907067, PMID:15536084
Nkp46 controls NK cytolitic activity via PI3K /RAC1/PAK1/MEK??/ERK pathway, probably throught SYK
PMID:11777960
ULBP2 through NKG2D induces SCF2 (GM-CSF), CLL4 (MIP1B) and IFNG secretion via PI3K pathway
PMID:12040186
The activated PI3K converts the plasma membrane lipid phosphatidylinositol-4,5-bisphosphate [PI(4,5)P2] to phosphatidylinositol-3,4,5-trisphosphate [PI(3,4,5)P3].
PMID:9438848
PI3K product phosphatidylinositol-3,4,5-trisphosphate enhanced phosphorylation and activation of Vav proteins
PMID:12393695
SHIP1 inhinits NK cells activation via bloking of PI3K pathway. It hydrolyzes the 5???-phosphate of PI3,4,5P3l eading to its conversion to PI3,4P2.
PMID:20363967, PMID:16204085
Src homology 2-containing inositol 5'-phosphatase 1 negatively regulates IFN-gamma production by natural killer cells stimulated with antibody-coated tumor cells and interleukin-12, probably via inhibition of PI3K pathway and downstream ERK signaling.

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. PIP3*@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. PDPK1:​PIP3*@INNATE_IMMUNE_CELL_Cytosol map
Participates in reactions:
As Reactant or Product:
  1. PIP2*@INNATE_IMMUNE_CELL_Cytosol map → map PIP3*@INNATE_IMMUNE_CELL_Cytosol map
  2. PDPK1@INNATE_IMMUNE_CELL_Cytosol map + PIP3*@INNATE_IMMUNE_CELL_Cytosol map → map PDPK1:​PIP3*@INNATE_IMMUNE_CELL_Cytosol map
  3. PIP3*@INNATE_IMMUNE_CELL_Cytosol map → map PIP2*@INNATE_IMMUNE_CELL_Cytosol map
As Catalyser:
  1. IFNG@INNATE_IMMUNE_CELL_Cytosol map → map IFNG@default map
  2. CCL4@INNATE_IMMUNE_CELL_Cytosol map → map CCL4@default map
  3. CSF2@INNATE_IMMUNE_CELL_Cytosol map → map CSF2@default map
  4. VAV2@INNATE_IMMUNE_CELL_Cytosol map → map VAV2@INNATE_IMMUNE_CELL_Cytosol map
  5. VAV3@INNATE_IMMUNE_CELL_Cytosol map → map VAV3@INNATE_IMMUNE_CELL_Cytosol map
  6. VAV1@INNATE_IMMUNE_CELL_Cytosol map → map VAV1|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map
  7. AKT*@INNATE_IMMUNE_CELL_Cytosol map → map AKT*|​pho@INNATE_IMMUNE_CELL_Cytosol map
  8. CYTH1@INNATE_IMMUNE_CELL_Cytosol map → map CYTH1@INNATE_IMMUNE_CELL_Cytosol map