Identifiers
HUGO:PDK1
pyruvate dehydrogenase kinase 1
HUGO:PDK1 hgnc_id:HGNC:8809 HGNC:8809 ENTREZ:5163 UNIPROT:Q15118
3-phosphoinositide dependent protein kinase-1
HUGO:PDPK1 HGNC:8816 ENTREZ:5170 UNIPROT:O15530
HUGO:PDPK1 HGNC:8816 ENTREZ:5170 UNIPROT:O15530 GENECARDS:PDPK1 REACTOME:61460 KEGG:5170 ATLASONC:GC_PDPK1 WIKI:PDPK1
Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
Adaptive Immune Response / TCR_SIGNALING
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
Cancer Associated Fibroblasts / CORE
EMT Senescence / EMT_REGULATORS
EMT Senescence / MITOCHONDRIA_OXIDATIVE_STRESS
HMC:RESISTING_CELL_DEATH
Regulated Cell Death / STARVATION_AUTOPHAGY
Regulated Cell Death / CASPASES
Regulated Cell Death / DEATH_RECEPTOR_PATHWAYS
Regulated Cell Death / DEPENDANCE_RECEPTORS
Innate Immunity / IMMUNOSTIMULATORY_CORE_PATHWAYS
HMC:EVADING_GROWTH_SUPPRESSORS
Survival / PI3K_AKT_MTOR
References
PMID:12670391 PMID:19122654 PMID:15802604
CASCADE:PDGF
PMID:11687500
Binding to second messenger lipids allows PDK1 and AKT (PKB) to interact with each other, resulting in the phosphorylation and consequent activation of AKT (PKB).
PMID:11747822
Akt but not SGK promotes cell motility downstream of the PI3-K-PDK1 pathway.
PMID:18802401
PMID:17680028
synonym:PDK1PMID:17604717
MACROPHAGE
CASCADE:IL4
PMID:19109239
IL4 induces he tyrosine phosphorylation of IRS-2 via Type I IL-4 Receptors. Activated IRS2 interacts with p85 subunit of PI3K and Grb2 and activates downstrean PI3K signaling (??phosphorylation of Akt on Ser473)