Identifiers
HUGO:AKT1
HUGO:AKT1 HUGO:AKT2 HUGO:AKT3
AKT serine/threonine kinase 1
HUGO:AKT1 hgnc_id:HGNC:391 HGNC:391 ENTREZ:207 UNIPROT:P31749
AKT serine/threonine kinase 2
HUGO:AKT2 hgnc_id:HGNC:392 HGNC:392 ENTREZ:208 UNIPROT:P31751
AKT serine/threonine kinase 3
HUGO:AKT3 hgnc_id:HGNC:393 HGNC:393 ENTREZ:10000 UNIPROT:Q9Y243
v-akt murine thymoma viral oncogene homolog 1
HUGO:AKT1, HGNC:391, ENTREZ:207, UNIPROT:P31749
v-akt murine thymoma viral oncogene homolog 2
HUGO:AKT2, HGNC:392, ENTREZ:208, UNIPROT:P31751
v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)
HUGO:AKT3, HGNC:393, ENTREZ:10000, UNIPROT:Q9Y243
HUGO:AKT1 HGNC:391 ENTREZ:207 UNIPROT:P31749 GENECARDS:AKT1 REACTOME:58253 KEGG:207 ATLASONC:AKT1ID355ch14q32 WIKI:AKT1
HUGO:AKT2 HGNC:392 ENTREZ:208 UNIPROT:P31751 GENECARDS:AKT2 REACTOME:49860 KEGG:208 ATLASONC:AKT2ID517ch19q13 WIKI:AKT2
HUGO:AKT3 HGNC:393 ENTREZ:10000 UNIPROT:Q9Y243 GENECARDS:AKT3 REACTOME:415917 KEGG:10000 ATLASONC:AKT3ID615ch1q44 WIKI:AKT3
HUGO:AKT3 HGNC:393 ENTREZ:10000 UNIPROT:Q9Y243 GENECARDS:AKT3 REACTOME:415917 KEGG:10000 ATLASONC:AKT3ID615ch1q44 WIKI:AKT3 HUGO:CDH2 HGNC:1759 ENTREZ:1000 UNIPROT:P19022 GENECARDS:CDH2 REACTOME:51212 KEGG:1000 ATLASONC:GC_CDH2 WIKI:CDH2
Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
Adaptive Immune Response / TCR_SIGNALING
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
Cancer Associated Fibroblasts / CORE
HMC:SUSTAINING_PROLIFERATIVE_SIGNALLING
Cell Cycle DNA Repair / G1_S_CHECKPOINT
HMC:RESISTING_CELL_DEATH
HMC:DEREGULATING_CELLULAR_ENERGETICS
Regulated Cell Death / APOPTOSIS
Regulated Cell Death / STARVATION_AUTOPHAGY
Regulated Cell Death / CASPASES
Regulated Cell Death / DEATH_RECEPTOR_PATHWAYS
Regulated Cell Death / DEPENDANCE_RECEPTORS
Regulated Cell Death / FATTY_ACID_BIOSYNTHESIS
Regulated Cell Death / GLUCOSE_METABOLISM
Regulated Cell Death / MITOCHONDRIAL_METABOLISM
Regulated Cell Death / MOMP_REGULATION
Regulated Cell Death / NECROPTOSIS
Regulated Cell Death / RCD_GENES
Innate Immunity / IMMUNOSTIMULATORY_CORE_PATHWAYS
HMC:EVADING_GROWTH_SUPPRESSORS
Survival / MAPK
Survival / HEDGEHOG
Survival / PI3K_AKT_MTOR
Survival / WNT_NON_CANONICAL
References
PMID:10625301 PMID:11532940
PMID:12670391 PMID:11135576 PMID:23087689 PMID:23732914 PMID:26552706 PMID:19406987 PMID:16962653 PMID:18566586
CASCADE:PDGF
PMID:11696562
Integrin-linked kinase (ILK) is a binding partner of the integrin 1 and 3 subunits and is involved in the signal transduction from integrin receptors
The activity is stimulated in a phosphatidylinositol (PI) 3-kinase???dependent manner and likely involves binding of the phosphoinositide phospholipid product of PI 3-kinase, PI 3,4,5-triphosphate, to the PH-like domain of ILK
ILK has been shown recently to directly phosphorylate proteins such as PKB (PKB/Akt) on ser 473.
PMID:27111285
ILK???PI3K/AKT pathway participates in cutaneous wound contraction by regulating fibroblast migration and differentiation to myofibroblast
PMID:25732845
Akt-Girdin signaling in cancer-associated fibroblasts contributes to tumor progression.
PMID:17397400
PDGF -receptor directly binds and activates PLC-gamma 1, RasGAP, P13K, and a 64 kd protein.
PI3K-Akt pathway promotes microtubule stabilization in migrating fibroblasts downstream of PDGF signaling
PMID:11747822
Akt but not SGK promotes cell motility downstream of the PI3-K-PDK1 pathway.
PMID:25924008
PMID:17604717
PMID:23030059
MACROPHAGE
NATURAL_KILLER
NEUTROPHIL
CASCADE:TGFB
CASCADE:LGALS3
CASCADE:IL4
CASCADE:IL15
CASCADE:IL21
CASCADE:CSF2
CASCADE:IFNG
PMID:22703233
TGFBR2 upregulates expression of markers M2 activation as ARG1, MCR2 and LGALS3 (galecsin3) and induces AKT activation.
PMID:18250477
Galectin-3 mediate alternative activation of macrophages via activation of PI3K signaling and AKT posphorylation. And regulates expression of MRC1 probably via PI3K
PMID:11687500
Binding to second messenger lipids allows PDK1 and AKT (PKB) to interact with each other, resulting in the phosphorylation and consequent activation of AKT (PKB).
PMID:24795729
IL15 induces IFNG production via PI3K/AKT/MTOR pathway.
PI3K???AKT???mTOR pathway is required for granzyme B production downstream of IL15.
Treatment with PI3K inhibitor abrogated the priming effect. Such inhibition was also observed
with blocking mTOR and AKT, downstream signaling components of PI3K pathway,
suggesting that PI3K???AKT???mTOR pathway is critical for optimal responses of ???primed??? NK cells to cytokine stimulations.
PMID:12906785, PMID:19022819
AKT activates Rapamycin associated protein FRAP2 ( mTOR ) probably through Tuberin/GTP-binding protein Ras homolog enriched in brain ( RHEB ) pathway.
PMID:19109239
IL4 induces he tyrosine phosphorylation of IRS-2 via Type I IL-4 Receptors. Activated IRS2 interacts with p85 subunit of PI3K and Grb2 and activates downstrean PI3K signaling (??phosphorylation of Akt on Ser473).
PMID:20805416
In differentiating moDCs, the PI3K/Akt-dependent mTOR pathway was constitutively activated by GM-CSF
And this signaling is needful for DC differentiation.
PMID:21826665
TLR4/PI3K /AKT signaling in TAN promotes motility of cancer cells
PMID:20214616
PMID:17680028
PMID:20398329
References
in_re1154( Innate Immunity ):
PMID:16713974
AKT kinases phosphorylate GSK3 proteins and inhibit its activity downstream of TLR signaling.
IFNG prevents this inactivation.