Protein GSK3_beta_* map

Identifiers
glycogen synthase kinase 3 beta
HUGO:GSK3B, HGNC:4617, ENTREZ:2932, GENECARDS:GC03M119540, UNIPROT:P49841??
HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841
HUGO:GSK3B
HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841 GENECARDS:GSK3B REACTOME:404223 ATLASONC:GSK3BID40761ch3q13 WIKI:GSK3B

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map
 EMT Senescence  map  / SENESCENCE  map
HMC:RESISTING_CELL_DEATH
HMC:DEREGULATING_CELLULAR_ENERGETICS
 Regulated Cell Death  map  / ANTIOXIDANT_RESPONSE  map
 Regulated Cell Death  map  / STARVATION_AUTOPHAGY  map
 Regulated Cell Death  map  / CASPASES  map
 Regulated Cell Death  map  / GLUCOSE_METABOLISM  map
 Regulated Cell Death  map  / MITOCHONDRIAL_METABOLISM  map
 Regulated Cell Death  map  / MOMP_REGULATION  map
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Innate Immunity  map  / IMMUNOSTIMULATORY_CORE_PATHWAYS  map
HMC:EVADING_GROWTH_SUPPRESSORS
 Survival  map  / MAPK  map
 Survival  map  / HEDGEHOG  map
 Survival  map  / PI3K_AKT_MTOR  map
 Survival  map  / WNT_CANONICAL  map

References
PMID:15465828
GSK-3b plays a critical role in cell survival by phosphorylating nuclear factor-??B (NF-??B) p65 subunit, leading to NF-??B transactivation in hepatocytes
This phosphorylation negatively regulates basal p65 NF-kappaB activity.
PMID:15020233
MEK1/2 can phosphorylate tyrosine 216, which stimulates GSK3B kinase activity
U0126, a MEK1/2 inhibitor, inhibited tyrosine phosphorylation of GSK3B, suggesting that MEK1/2 was involved in the phosphorylation of Tyr216 in GSK3B
In vitro kinase interaction showed that GSK3B is phosphorylated by recombinant MEK1 at Y216
PMID:16944320
The enzymatic activity of GSK3 is enhanced by phosphorylation of tyrosine-216 in GSK3b
GSK3 is considered to be largely a cytosolic enzyme, but it is also associated with, or internalized in, subcellular compartments such as the nucleus, mitochondria, and growth cones
PMID:9832503
GSK3 is predominatly cytoplasmic during G1 phase of the celle cycle, but a significant fraction enters the nucleus during S phase, promoting its ability to phosphorylate cyclin D1 in the nucleus
Phosphorylation of cyclin D1 on a single threonine residue near the carboxyl terminus (Thr-286) positively regulates proteasomal degradation of D1
GSK3 phosphorylates cyclin D1 specifically on Thr-286, thereby triggering rapid cyclin D1 turnover.
PMID:14663202
GSK3B is highly activated in nuclei and mitochondria.
PMID:11967263
Tyr-216 phosphorylation is required for GSK-mediated down-regulation of b-catenin activity.
PMID:8524413
Inactiviation of GSK-3 occurs through Akt phosphorylation of serine 9 of GSK-3b.
This phosphorylation may be involved in later phases of neuronal apoptosis.
Mutation of Ser9 to Ala did not affect GSK-3 -mediated phosphorylation of b-catenin, whereas mutation of Tyr216 to Phe markedly reduced the in vivo phosphorylation of b-catenin.
PMID:16713974
GSK3B inhitits activation (DNA binding) of AP-1 factors.
GSK3B is activated downstrean of IFNG via PI3K pathway.
PMID:16007092
GSK3B inhibits CREB1 interaction with CBP and inhibits CREB1 dependent IL10 expression.
CREB1/CBP complex formation prevents binding CBP to RELA (p65) and inhibits downstream NF-kB signaling.
ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex.
PMID:16039586
PMID:12615961
PMID:20537194
glycogen synthase kinase 3

GSK3_beta_*@INNATE_IMMUNE_CELL_Cytosol

References
in_re1154( Innate Immunity  map ):
PMID:16713974
AKT kinases phosphorylate GSK3 proteins and inhibit its activity downstream of TLR signaling.
IFNG prevents this inactivation.
in_re1281( Innate Immunity  map ):
TLR activation of CREB by phosphorylation of serine-133 is dependent on p38.
GSK3B inhibits IL10 expression downstream of IFNG, probably via GREB1 inhibition.
PMID:16007092
GSK3B inhibits CREB1 interaction CBP and inhibits CREB1 dependent IL10 expression.

GSK3_beta_*|​pho@INNATE_IMMUNE_CELL_Cytosol

References
in_re1154( Innate Immunity  map ):
PMID:16713974
AKT kinases phosphorylate GSK3 proteins and inhibit its activity downstream of TLR signaling.
IFNG prevents this inactivation.

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. GSK3_beta_*@INNATE_IMMUNE_CELL_Cytosol map
  2. GSK3_beta_*|​pho@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. GSK3_beta_*@INNATE_IMMUNE_CELL_Cytosol map → map GSK3_beta_*|​pho@INNATE_IMMUNE_CELL_Cytosol map
    2. GSK3_beta_*@INNATE_IMMUNE_CELL_Cytosol map → map GSK3*@INNATE_IMMUNE_CELL_Cytosol map
    As Catalyser:
    1. CREB1@INNATE_IMMUNE_CELL_Cytosol map → map CREB1|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map
    2. CBP*@INNATE_IMMUNE_CELL_Cytosol map + RELA@INNATE_IMMUNE_CELL_Cytosol map → map CBP*:​RELA@INNATE_IMMUNE_CELL_Cytosol map
    3. CREB1|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map + CBP*@INNATE_IMMUNE_CELL_Cytosol map → map CBP*:​CREB1|​pho@INNATE_IMMUNE_CELL_Cytosol map