Protein GSK3* map

Identifiers
HUGO:GSK3B HUGO:GSK3A
HUGO:GSK3A
HUGO:GSK3B
glycogen synthase kinase 3 alpha
HUGO:GSK3A HGNC:4616 ENTREZ:2931 UNIPROT:P49840 GENECARDS:GSK3A REACTOME:69666 ATLASONC:GC_GSK3A WIKI:GSK3A
glycogen synthase kinase 3 beta
HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841 GENECARDS:GSK3B REACTOME:404223 ATLASONC:GSK3BID40761ch3q13 WIKI:GSK3B

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Adaptive Immune Response  map  / TCR_SIGNALING  map
 Innate Immunity  map  / IMMUNOSTIMULATORY_CORE_PATHWAYS  map
HMC:EVADING_GROWTH_SUPPRESSORS
 Survival  map  / WNT_CANONICAL  map
 Survival  map  / WNT_NON_CANONICAL  map

References
PMID:19836308 PMID:26885856 PMID:23732914
PMID:16713974
AKT kinases phosphorylate GSK3 proteins and inhibit its activity downstream of TLR signaling.
IFNG prevents this inactivation.
PMID:19366350

GSK3*@INNATE_IMMUNE_CELL_Cytosol

References
in_re1149( Innate Immunity  map ):
PMID:16713974
GSK3B inhitits activation (DNA binding) of AP-1 factors.
JNK is a classical activator of AP1 transcription factors.
Inhibition of JNK downregulates IL10 expression. Probably via
AP1.

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. GSK3*@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. GSK3_alpha_*@INNATE_IMMUNE_CELL_Cytosol map → map GSK3*@INNATE_IMMUNE_CELL_Cytosol map
    2. GSK3_beta_*@INNATE_IMMUNE_CELL_Cytosol map → map GSK3*@INNATE_IMMUNE_CELL_Cytosol map
    As Catalyser:
    1. AP1*@INNATE_IMMUNE_CELL_Cytosol map → map AP1*|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map
    2. _beta_-Catenin*@INNATE_IMMUNE_CELL_Cytosol map → map _beta_-Catenin*|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map