Reaction state_transition in_re1149
AP1*@INNATE_IMMUNE_CELL_Cytosol
→ AP1*|pho|active@INNATE_IMMUNE_CELL_Cytosol
Reaction regulators:
- Catalysis
- JNK*|pho|active@INNATE_IMMUNE_CELL_Cytosol
- ERK1/2*|pho@INNATE_IMMUNE_CELL_Cytosol
- Inhibition
- GSK3*@INNATE_IMMUNE_CELL_Cytosol
References
PMID:16713974
GSK3B inhitits activation (DNA binding) of AP-1 factors.
JNK is a classical activator of AP1 transcription factors.
Inhibition of JNK downregulates IL10 expression. Probably via
AP1.